Nonanal

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

No data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Sedion 191.10 of the Final Order. Enforcement Regulations. United States Federal Register, Vol. 26, No. 155, p 7336 1961-08-12

GLP compliance:

no

Remarks:

study predates GLP

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Nonanal

EC Number:

204-688-5

EC Name:

Nonanal

Cas Number:

124-19-6

Molecular formula:

C9H18O

IUPAC Name:

nonanal

Specific details on test material used for the study:

- Name of test material (as cited in study report): Aldehdyde C-9, EAO 71-14
- Substance type: No data
- Physical state: No data
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No.: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data
- Other: Tested as supplied

Test animals

Species:

rabbit

Strain:

other: Albino (probably New Zealand White)

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Details on dermal exposure:

TEST SITE
- Area of exposure: No data
- % coverage: No data
- Type of wrap if used: No data
- 3 rabbits' skin left intact; 3 rabbits' skin abraded.

REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: No data

TEST MATERIAL
- Volume or weight applied: No data

Duration of exposure:

Single exposure

Doses:

5 g/kg bw

No. of animals per sex per dose:

6 animals (sex not specified) per single dose.

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: No data
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: No data

Statistics:

None

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

1/6 (1 rabbit from abraded group died on day 4)

Clinical signs:

other: Severe oedema and burns

Gross pathology:

No data

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The test substance was assessed for acute dermal toxicity in albino rabbits. The LD50 was > 5000 mg/kg body weight.