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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011-04-18
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study.
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Names of test material (as cited in study report): Aldehyde C9 nonyl food grade; nonanal
- Substance type: Colourless liquid to pale yellow liquid
- Physical state: Liquid
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot No: VE00120901
- Expiration date of the lot: 2011-10-14
- Stability under test conditions: No data
- Storage condition of test material: No data
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
3.4
Temp.:
35 °C
Remarks on result:
other: pH not determined
Details on results:
PEAK
A peak was obtained at 9.20 minutes

HPLC PROCEDURE
- Representative chromatograms are presented in Appendices 3 and 4 (attached).

NOTE
The determination was performed at 35 °C (temperature of the column) but the value obtained can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Pow values were determined. Partition coefficients of the test and reference substances are assumed to vary with temperature in the same way.
Conclusions:
The n-octanol/water partition coefficient (Log Pow) of the test substance was determined to be 3.4

Description of key information

Log Pow 3.4 (OECD 117)

Key value for chemical safety assessment

Log Kow (Log Pow):
3.4
at the temperature of:
35 °C

Additional information

The determination was performed at 35 °C (temperature of the column) but the value obtained can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Pow values were determined.