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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract only.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Paragraph 191.1(f)(1) of the Final Order, Enforcement Regulations, United States Federal Register. Vol. 26, No. 155, p. 7336, 1961-08-12
GLP compliance:
no
Remarks:
Study predates GLP
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Sherman-Wistar
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Fasting period before study: 24 hours
- Diet: Available ad libitum
- Water: Available ad libitum
- Acclimation period: 1 week

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
5000 mg/kg
No. of animals per sex per dose:
5 animals/sex
Control animals:
no
Details on study design:
Animals were observed for 14 days.
Statistics:
None

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortalities were observed.
Clinical signs:
Diuresis was noted soon after dosing followed by lethargy and dullness. Recovery was complete 24-48 hours after dosing.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test material was assessed for acute oral toxicity using rats exposed to the test material by oral gavage. The acute oral LD50 for the test material was >5000 mg/kg bw.