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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Used in risk assessment report for zinc chloride, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
65Zinc uptake from blood into brain and other tissues in the rat.
Author:
Pullen R.G.L.
Year:
1990
Bibliographic source:
Neurochem. Res. 15, 1003-1008.
Reference Type:
secondary source
Title:
EU Risk Assessment Report Zinc chloride, Volume 45
Author:
Munn S.J. et al.
Year:
2004
Bibliographic source:
Luxembourg: Office for Official Publications of the European Communities 2004-VIII pp., 116 pp.

Materials and methods

Objective of study:
distribution
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The tissue uptake of 65Zn2+ (as zinc chloride) was determined in adult male Wistar rats after intraperitoneal injection of 15 µCi 65Zn2+.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Zinc chloride
Radiolabelling:
not specified

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Duration and frequency of treatment / exposure:
No data
Doses / concentrations
Dose / conc.:
15 other: µCi 65Zn2+
No. of animals per sex per dose:
No data
Control animals:
not specified

Results and discussion

Preliminary studies:
Not applicable

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Not applicable
Details on distribution in tissues:
The liver displayed the greatest uptake for zinc ions, followed by the kidney, pancreas, spleen, ileum, lung, heart, bone, testis, blood cells, muscle and brain. Additional data on Zn2+ uptake by the brain indicate that the blood-brain barrier is minimally permeable to zinc cations.
Transfer into organs
Transfer type:
other: Not reported
Details on excretion:
Not applicable
Toxicokinetic parameters
Toxicokinetic parameters:
other: Not applicable

Metabolite characterisation studies

Metabolites identified:
not measured
Details on metabolites:
Not applicable

Any other information on results incl. tables

None

Applicant's summary and conclusion

Conclusions:
Bioaccumulation potential can not be judged based on study results. The liver displayed the greatest uptake for zinc ions, followed by the kidney, pancreas, spleen, ileum, lung, heart, bone, testis, blood cells, muscle and brain.
Executive summary:

The tissue uptake of 65Zn2+ (as zinc chloride) was determined in adult male Wistar rats after intraperitoneal injection of 15 µCi 65Zn2+. The liver displayed the greatest uptake for zinc ions, followed by the kidney, pancreas, spleen, ileum, lung, heart, bone, testis, blood cells, muscle and brain. Additional data on Zn2+ uptake by the brain indicate that the blood-brain barrier is minimally permeable to zinc cations.