Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-178-9 | CAS number: 16039-53-5
The toxicokinetics and metabolism of zinc dilactate can be understood in terms of the toxicokinetics and metabolism of the fully dissociating salt components lactate anion and zinc(II) cation. Information on lactic acid and zinc chloride is used for read-across.
Lactic acid is a ubiquitous and essential biological molecule, in humans and other mammals, but also in most if not all vertebrate and invertebrate animals, as well as in many micro-organisms. As such the biokinetics, metabolism and distribution of lactic acid have to be considered in the context of its normal biochemistry; exogenous lactic acid will be indistinguishable from endogenous lactic acid and will follow the same biochemical pathways as endogenous lactic acid, at least up to a certain systemic level.
The biochemistry of lactic acid has been reviewed and summarized in Sterenborg, 2007.
Dermal absorption of lactic acid is not a toxicologically relevant pathway, since lactic acid is a natural constituent of the human dermis and epidermis. Lactic acid is frequently used as a humectant in leave-on skin cosmetics, where its main mode of action is through its sequestration in the stratum corneum, where it will aid in attracting water into the SC and holding it there. The cosmetics-oriented skin penetration studies clearly supports the notion that lactic acid does not penetrate the skin, but is sequestered in the SC, and even there only up to ca 16% of the applied amount.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again