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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Used in risk assessment report for zinc chloride, however the study gives too little details to be used for risk assessment.
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
A comparative investigation of the percutaneous absorption of metal compoundsin the guinea pig by means of the radioactive isotopes: 51Cr, 58Co, 65Zn, 110mAg, 115mCd, 203Hg.
Author:
Skog E. and Wahlberg J.E.
Year:
1964
Bibliographic source:
J. Invest. Dermatol. 43, 187-192.
Reference Type:
secondary source
Title:
EU Risk Assessment Report Zinc chloride, Volume 45
Author:
Munn S.J. et al.
Year:
2004
Bibliographic source:
Luxembourg: Office for Official Publications of the European Communities 2004-VIII pp., 116 pp.

Materials and methods

Principles of method if other than guideline:
A percutaneous absorption study was conducted to evaluate the uptake of 65[Zn]-chloride by the dorsal skin of the guinea pig when tested at concentrations ranging from 0.8 to 4.87 M ZnCl2 (pH 1.8-6.1).

GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Zinc chloride
EC Number:
231-592-0
EC Name:
Zinc chloride
Cas Number:
7646-85-7
IUPAC Name:
zinc dichloride
Details on test material:
- Name of test material (as cited in study report): Zinc chloride
- Half life: 245 d
Radiolabelling:
yes

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Duration of exposure:
5 h
Doses:
- Concentrations: 0.8 to 4.87 M (pH 1.8-6.1)
- Rationale for dose selection: The lowest and highest concentration were chosen on account of the specific activity of the isotope and limiting solubility in distilled water at room temperature respectively.
- Replicates: 10 trials at each concentartion
No. of animals per group:
Not reported
Control animals:
no

Results and discussion

Conversion factor human vs. animal skin:
No data

Any other information on results incl. tables

- Disappearance percentage during a 5-hour period was less than 1%, except for the trials with the lowest pH where it was between 1 and 2%.

Applicant's summary and conclusion

Conclusions:
Under the conditions of the test, decline of radioactivity emitted by 65[Zn]-chloride after 5 hours was less than 1% except for the trials with the lowest pH where it might have been between 1 and 2% .
Executive summary:

A percutaneous absorption study was conducted to evaluate the uptake of 65[Zn]-chloride by the dorsal skin of the guinea pig. The decline of radioactivity emitted by 65[Zn]-chloride was monitored in at least 10 trials for each concentration tested ranging from 0.8 to 4.87 M ZnCl2 (pH 1.8-6.1). Under the conditions of the test, decline of radioactivity emitted by 65[Zn]-chloride after 5 hours was less than 1% except for the trials with the lowest pH where it might have been between 1 and 2%.