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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report Date:
1978

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No guideline available in the report.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No additional information available.

Test animals / tissue source

Species:
rabbit
Strain:
other: albino

Test system

Vehicle:
other: undiluted or 5 or 15% dilution in propylene glycol
Controls:
not specified
Amount / concentration applied:
Five rabbits were dosed in one eye with 0.005 ml of undiluted material.
Four rabbits were dosed in one eye with 0.5 ml of a 15% dilution in propylene glycol.
Additional eyes, number unstated, were dosed with 0.5 ml of a 5% dilution in propylene glycol.
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
Eyes are scored immediately unstained and after 24 hours following fluorescein administration.
Number of animals or in vitro replicates:
Various, see above.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other:
Remarks on result:
other: 0.005 mL of the undiluted substance resulted in moderate to severe injury with iritis in 2 of 5 eyes.
Irritation parameter:
other:
Remarks on result:
other: 0.5 mL of a 15 % dilution resulted in severe corneal injury with iritis in 2 of 4 eyes.
Irritation parameter:
other:
Remarks on result:
other: 0.5 mL of a 5 % dilution resulted in no corneal injury.
Irritant / corrosive response data:
Undiluted material - 0.005 ml resulted in moderate to severe corneal injury with iritis in 2 of 5 eyes.

15% dilution - 0.5 ml resulted in severe corneal injury with iritis in 2 of 4 eyes.

5% dilution - 0.5 ml resulted in no corneal injury.
Other effects:
Undiluted material - 0.005 ml resulted in moderate to severe corneal injury with iritis in 2 of 5 eyes.

15% dilution - 0.5 ml resulted in severe corneal injury with iritis in 2 of 4 eyes.

5% dilution - 0.5 ml resulted in no corneal injury.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

Conclusions:
Instillation of the undiluted or diluted material resulted in moderate to severe corneal injury, with iritis, in rabbit eyes. However, as the study was not conducted according to current guidelines the results do not allow to classify according to EU criteria.
Executive summary:

The eye irritation potential of n-pentanol was examined. Instillation of the undiluted or diluted material resulted in moderate to severe corneal injury, with iritis, in rabbit eyes.