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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles For justification of read across please refer to section 13.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Sensory response to certain industrial solvent vapors
Author:
Nelson KW et al.
Year:
1943
Bibliographic source:
J . ind. Hrg. Toxicol. 25, 282
Reference Type:
secondary source
Title:
Fragrance raw materials monographs - Isoamyl alcohol
Author:
Opdyke DLJ
Year:
1978
Bibliographic source:
Food Chem. Tox. 16, S1, 785-788
Reference Type:
secondary source
Title:
No information
Author:
Rowe and McCollister
Year:
1982
Bibliographic source:
Patty's Ind. Hyg. Toxicol., 3rd ed., vol 2, page 2658

Materials and methods

Type of study / information:
Inhalation study
Endpoint addressed:
respiratory irritation
Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Isoamyl alcohol
- Analytical purity: no data

Method

Ethical approval:
not specified
Details on study design:
The procedure followed in this study consisted of the exposure of an average number of ten persons, of mixed sexes, to a given concentration of solvent vapour for a period of 3 to 5 min, in a 1200 cubic foot gas cabinet.
After the exposure, each individual classified the effect of the vapour on the eyes, nose, and throat. The classifications were: no reaction, slightly irritating, and very irritating.
The odor was listed as absent, definite, moderate, strong, or overpowering.
Finally, each person was asked if he believed he could work in the atmosphere for an eight-hour day.
Exposure assessment:
not specified
Details on exposure:
TYPE OF EXPOSURE: inhalation

EXPOSURE LEVELS: 100 - 150 ppm (corresponding to approx. 0.366 - 0.549 mg/L)

EXPOSURE PERIOD: 3 - 5 min

Results and discussion

Results:
Irritating to the throat at 100 ppm (equivalent to approx. 0.366 mg/L) and to the eyes and nose at 150 ppm (equivalent to approx. 0.549 mg/L).
The highest concentration which the majority of subjects estimated as acceptable for an 8-hour exposure was < 100 ppm (equivalent to approx. 0.366 mg/L).

Applicant's summary and conclusion