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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Food flavorings and compounds of related structure I. Acute Oral Toxicity
Author:
Jenner PM et al.
Year:
1964
Bibliographic source:
Food Cosmet. Toxicol. 2, 327-343
Reference Type:
secondary source
Title:
Toxicity and metabolsim of industrial solvents
Author:
Browning E
Year:
1973
Bibliographic source:
Med. Res. Council Ind. Health Res. Board,Rep.No. 80, H.M. Stationery Office, London
Reference Type:
secondary source
Title:
1-Pentanol
Author:
Rowe VK and McCollister SB
Year:
1982
Bibliographic source:
Patty's Industrial Hygiene and Toxicology, 3rd rev. ed., Wiley, New York, pp. 4527–4708
Reference Type:
secondary source
Title:
Die Situation in der gesundheitlichen Beurteilung der Aromatisierungsmittel fur Lebensmittel
Author:
Bär VF and Griepentrog F
Year:
1967
Bibliographic source:
Medizin Ernahr., 8, 244-251

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Amyl alcohol (pentanol)

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALSTEST ANIMALS
- Fasting period before study: 18 hours

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
no data
No. of animals per sex per dose:
5
Control animals:
other: other substances
Details on study design:
- Duration of observation period following administration: 14 days
Other examinations performed: clinical signs, mortality
Statistics:
LD50 values were calculated per Litchfield-Wilcoxon (1949)

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 030 mg/kg bw
95% CL:
1 440 - 6 360
Remarks on result:
other: slope = 1.2 (1.0 - 1.4)
Mortality:
Death from a few minutes to 18 hours
Clinical signs:
Depression

Applicant's summary and conclusion