Registration Dossier
Registration Dossier
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EC number: 200-752-1 | CAS number: 71-41-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Penetration of low-molecular-weight alcohols into skin. Effect of concentration of alcohol and type of vehicle
- Author:
- Blank IH
- Year:
- 1 964
- Bibliographic source:
- Journal of Investigative Dermatology, 43(5), 415-420
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- RIFM
- Year:
- 2 009
- Bibliographic source:
- RIFM database
- Reference Type:
- secondary source
- Title:
- 1-Pentanol
- Author:
- Rowe VK and McCollister SB
- Year:
- 1 982
- Bibliographic source:
- Patty's Industrial Hygiene and Toxicology, 3rd rev. ed., Wiley, New York, pp. 4527–4708
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Skin penetration was studied quantitatively using excised human skin.
- GLP compliance:
- no
Test material
- Reference substance name:
- Pentan-1-ol
- EC Number:
- 200-752-1
- EC Name:
- Pentan-1-ol
- Cas Number:
- 71-41-0
- Molecular formula:
- C5H12O
- IUPAC Name:
- pentan-1-ol
Constituent 1
Test animals
- Species:
- human
- Sex:
- not specified
Administration / exposure
- Vehicle:
- other: saline, olive oil
- Duration of exposure:
- no data
- Control animals:
- yes
- Remarks:
- other alcohols
- Details on study design:
- Test:
- human abdominal skin, removed at autopsy within 12 hr of death
Results and discussion
- Absorption in different matrices:
- As the solubility of the alcohols in nonpolar liquids increases from methanol to octanol, the rate of penetration from an aqueous solution also increases. The alcohols penetrate more rapidly from vehicles in which they are less soluble. The rate of penetration of n-amyl alcohol from saline is about 20 times that of ethanol and about one-ninth that of octanol.
Any other information on results incl. tables
The rate of penetration of n-amyl alcohol from a solution of olive oil does not continue to increase as the concentration becomes high; the rate becomes maximal at given point and thereafter decreases as the concentration continues to rise.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
