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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-finding toxicity data: List VII
Author:
Smyth Jr. HF et al.
Year:
1969
Bibliographic source:
American Industrial Hygiene Association Journal (AIHAJ), 30(5), 470-476
Reference Type:
secondary source
Title:
No information
Author:
RIFM
Year:
2008
Bibliographic source:
RIFM database

Materials and methods

Principles of method if other than guideline:
acc. to Smyth HF et al. (1962). Range-Finding Toxicity Data: List VI. Am. Ind. Hyg. Assoc. J. 23: 95-107

GLP compliance:
no
Test type:
other: inhalation hazard test
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 3-Methyl-1-butanol

Test animals

Species:
rat
Strain:
other: albino
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: room air
- System of generating particulates/aerosols: The test material (50 - 100 grams) was spread over a shallow tray which was placed in a 120-liter sealed chamber for a minimum of 24 hours
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
8 h
Concentrations:
concentrated vapour
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
ca. 10 mg/L air
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: calculated acc. to formula: vapour saturation (mg/l) = 0.0412 * vapour pressure (hPa) * molecular weight (g/mol); Inhalation hazard test
Mortality:
No mortality within the 14 day observation period after exposure of 8 h.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU