Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

No data were located for methylformate, but there is sufficient evidence that methylformate is not sensitising. There is no structural alert that methylformate itself binds to proteins to cause sensitisation. Formic acid and methanol may result from the enzymatic cleavage of methylformate. Both formic acid and methanol were negative in valid sensitisation studies using Guinea pigs in a Buehler test and in Magnussen-Kligman test, respectively.


Migrated from Short description of key information:
There is sufficient evidence that methylformate is not sensitising.

Justification for classification or non-classification

No classification as there is sufficient evidence that methylformate is not sensitising.