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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations. 

Key value for chemical safety assessment

EC50 for microorganisms:
8 117 mg/L

Additional information

Parent compound methyl formate

The key study regarding toxicity to microorganisms is a growth inhibition test with Pseudomonas putida following the German Industrial Standard DIN 38412, part 8. The EC50was determined to be > 10000 mg/L. The EC10 is 8117 mg/L (BASF AG, 1988).

Hydrolysis product formic acid/formate

As key study regarding toxicity to microorganisms, an inhibition control of a test on ready biodegradability according to EU method C.3 was identified, using domestic activated sludge as inoculum. Within the test period of 13 days, no inhibition of degradation activity could be observed. Hence, the test substance concentration of 72 mg/L is considered to be the NOEC (BASF, 1988).

Hydrolysis product methanol

In an activated sludge respiration inhibition test according to OECD TG 209 an EC50 value of >1000 mg/L was reported by Klecka et al. (1985).