Registration Dossier
Registration Dossier
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EC number: 203-481-7 | CAS number: 107-31-3
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment. Restrictions: purity of test substance not reported. Tested dose levels not reported.
Data source
Reference
- Reference Type:
- publication
- Title:
- Aliphatic alcohols and alkyl esters: narcotic and lethal potencies to tadpoles and rabbits.
- Author:
- Munch JC
- Year:
- 1 972
- Bibliographic source:
- Industrial Medicine 41, 31-33.
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl formate
- EC Number:
- 203-481-7
- EC Name:
- Methyl formate
- Cas Number:
- 107-31-3
- Molecular formula:
- Câ‚‚Hâ‚„Oâ‚‚
- IUPAC Name:
- methyl formate
- Details on test material:
- TS-Freetext:
Homologous series of aliphatic alcohols and their alkyl
esters. Included methyl formate.
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other: oral
- Vehicle:
- physiological saline
- Frequency of treatment:
- Single dose
- Details on study design:
- Observation period: 24 hours
Results and discussion
Any other information on results incl. tables
RS-Freetext:
(1) Narcotic and lethal doses of methyl formate:
ND50 = 27 millimols/kg bw.
LD50 = 27 millimols/kg bw.
27 millimols/kg bw correspond to 1620 mg/kg bw.
(2) Margin of safety: LD50/ND50=1.0
(3) The narcotic potential and the toxicity of the methyl
esters (formate, acetate, propionate, butyrate, isovalerate)
were much higher (by factors of 5-10) than the alcohol,
methanol. To a lower extent this effect was also seen with
ethanol, whereas in the C3-C5 series the potencies of the
alcohol and their esters were comparable to each other.
The narcotic potential and toxicity of the methyl esters
(only formate shown in the table below) was much higher
compared to the alcohol.
====================================================
ND50 LD50 [mmol/kg bw]
----------------------------------------------------
Methanol: 187.5 450
methyl formate: 27 27
====================================================
Applicant's summary and conclusion
- Conclusions:
- In rabbits, narcosis (ND50) and mortality (LD50) occurred
with methyl formate at the same oral dose (approx. 1620
mg/kg bw). Thus there was no margin of safety.
The narcotic potential and toxicity of the ester was much
higher compared to the alcohol.
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