Registration Dossier
Registration Dossier
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EC number: 203-481-7 | CAS number: 107-31-3
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: clinical case report
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- Gettler AO
- Year:
- 1 940
- Bibliographic source:
- Am J Clin Path 10, 188-190.
- Reference Type:
- publication
- Title:
- The aliphatic acids and their esters - toxicity and potential dangers.
- Author:
- von Oettingen WF
- Year:
- 1 959
- Bibliographic source:
- Arch Ind Health 20, 517-531.
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- dermal absorption
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl formate
- EC Number:
- 203-481-7
- EC Name:
- Methyl formate
- Cas Number:
- 107-31-3
- Molecular formula:
- C₂H₄O₂
- IUPAC Name:
- methyl formate
- Details on test material:
- parasiticide, evidently containing methyl formate
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 1
- Age: 19 months - Ethical approval:
- not applicable
- Remarks:
- clinical case report
- Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
- Details on exposure:
- A fatal case of methyl formate poisoning in a 19-months old child was reported whose scalp had been treated with a parasiticide, evidently containing methyl formate, and subsequently covered for 20 min with a rubber cap.
- Examinations:
- Post mortem determination of methyl formate in brain and liver.
Results and discussion
- Clinical signs:
- When the cap was removed after 20 minutes, the child collapsed, became cyanotic, and breathed slowly.
- Results of examinations:
- Methyl formate was found to be present in the brain. After hydrolysis to methanol, the methyl formate tissue burden was calculated to be 236 mg/kg in brain and 220 mg/kg in liver.
- Effectivity of medical treatment:
- No effective treatment
- Outcome of incidence:
- The child died from cardiac arrest. Brain, lings, liver, kidneys, and spleen were found highly congested.
Applicant's summary and conclusion
- Executive summary:
Methyl formate may be dermally absorbed.
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