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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: MH-20/2014
Water solubility:
197 g/L
Conc. based on:
test mat.
Temp.:
20 °C
Remarks on result:
other: Without correction of the purity.

Preliminary Visual Estimation of the Water Solubility

Table: Appearance of the test mixtures in the preliminary test

Amount of the test item in mg

Total volume in ml

Appearance of mixture

10

0.1

Dissolved

0.5

Dissolved

1.0

Dissolved

The preliminary visual experiments showed that the water solubility of the test item is above 100 g/l.

 

Flask-Method

 Table: Water solubility of the test item – experiments A to D

Experiment

A

B

C

D (blank)

Amount of test item (mg)

4000

4000

4000

---

Stirring time at 30 °C (h)

24

48

72

72

Aliquot

0.025/10/0.05/10

0.025/10/0.05/10

0.025/10/0.05/10

0.05/10/0.05/10

Measured concentration (μg/ml)

24.4

24.6

24.8

n.d.

Water solubility (g/l)

195

197

199

---

Average experiments A to C: 197 g/l

 

Table: Standard addition for recheck

Standard

Measured concentration

(μg/ml)

% Recovery

Sample C + 33 μg test item

57.2

98.2

 The recovery of 98.2 % indicates a sufficient accuracy of the analytical method.

Conclusions:
The water solubility of FAT 40061/F at 20 °C was determined to be 197 g/l.
Executive summary:

The purpose of the study was to determine the water solubility of FAT 40061/F according to EU Method A.6 and OECD Guideline 105. Flask method was used for this purpose. Based on the findings of the study, the water solubility of FAT 40061/F at 20 °C was determined to be 197 g/l.

Description of key information

The water solubility of FAT 40061/F was determined according to EU Method A.6 and OECD Guideline 105. Flask method was used for this purpose. Based on the findings of the study, the water solubility of FAT 40061/F at 20 °C was determined to be 197 g/l.

Key value for chemical safety assessment

Water solubility:
197 g/L
at the temperature of:
20 °C

Additional information