Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experiment start date - 23 February 2015; Experiment completion date - 27 February 2015; Study completion date - 06 March 2015.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Identification: FAT 20004/J TE Lot. 131390
Appearance: Yellow powder
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
-2.18
Temp.:
20 °C
Remarks on result:
other: pH is not known
Details on results:
Calculation of the partition coefficient log Pow from the individual solubilities
By means of the flask method, the saturation concentration of the test item in n-octanol was determined to: 432 mg/l.
By means of the flask method, the saturation concentration of the test item in water was determined to: 65.5 g/l
Conclusions:
The partition coefficient n-octanol/water of the test item at 20°C, from the individual solubilities in water and n-octanol, was determined to:
log P ow = -2.18
Executive summary:

The partition coefficient n-octanol/water of the test item was determined according to method A.8 and OECD test guideline 107. The estimated logPOW is out of the range (-2 to 4), the partition coefficient n-octanol/water has to be estimated from the individual solubilities in water and n-octanol.. According to this preliminary test the solubility of the test item in n-octanol is about 400 mg/l (without correction for the purity).

The partition coefficient n-octanol/water of the test item at 20°C, from the individual solubilities in water and n-octanol, was determined to: log P ow = -2.18

Description of key information

The partition coefficient n-octanol/water of the test item at 20 °C was determined to: Log Pow = -2.18

Key value for chemical safety assessment

Log Kow (Log Pow):
-2.18
at the temperature of:
20 °C

Additional information

The partition coefficient n-octanol/water of the test item was determined according to method A.8 and OECD test guideline 107. The estimated logPOW is out of the range (-2 to 4), the partition coefficient n-octanol/water has to be estimated from the individual solubilities in water and n-octanol. According to this preliminary test the solubility of the test item in n-octanol is about 400 mg/l (without correction for the purity). The partition coefficient n-octanol/water of the test item at 20 °C, from the individual solubilities in water and n-octanol, was determined to: log Pow = -2.18