Sodium 3-[[3-methoxy-4-[(4-methoxyphenyl)azo]phenyl]azo]benzenesulphonate

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experiment start date - 23 February 2015; Experiment completion date - 27 February 2015; Study completion date - 06 March 2015.

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

GLP compliance:

no

Type of method:

shake-flask method to: flask method

Partition coefficient type:

octanol-water

Specific details on test material used for the study:

Identification: FAT 20004/J TE Lot. 131390
Appearance: Yellow powder

Analytical method:

high-performance liquid chromatography

Type:

log Pow

Partition coefficient:

-2.18

Temp.:

20 °C

Remarks on result:

other: pH is not known

Details on results:

Calculation of the partition coefficient log Pow from the individual solubilities
By means of the flask method, the saturation concentration of the test item in n-octanol was determined to: 432 mg/l.
By means of the flask method, the saturation concentration of the test item in water was determined to: 65.5 g/l

Conclusions:

The partition coefficient n-octanol/water of the test item at 20°C, from the individual solubilities in water and n-octanol, was determined to:
log P ow = -2.18

Executive summary:

The partition coefficient n-octanol/water of the test item was determined according to method A.8 and OECD test guideline 107. The estimated logPOW is out of the range (-2 to 4), the partition coefficient n-octanol/water has to be estimated from the individual solubilities in water and n-octanol.. According to this preliminary test the solubility of the test item in n-octanol is about 400 mg/l (without correction for the purity).

The partition coefficient n-octanol/water of the test item at 20°C, from the individual solubilities in water and n-octanol, was determined to: log P ow = -2.18

Description of key information

The partition coefficient n-octanol/water of the test item at 20 °C was determined to: Log Pow = -2.18

Key value for chemical safety assessment

Log Kow (Log Pow):

-2.18

at the temperature of:

20 °C

Additional information

The partition coefficient n-octanol/water of the test item was determined according to method A.8 and OECD test guideline 107. The estimated logPOW is out of the range (-2 to 4), the partition coefficient n-octanol/water has to be estimated from the individual solubilities in water and n-octanol. According to this preliminary test the solubility of the test item in n-octanol is about 400 mg/l (without correction for the purity). The partition coefficient n-octanol/water of the test item at 20 °C, from the individual solubilities in water and n-octanol, was determined to: log Pow = -2.18