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EC number: 264-129-6 | CAS number: 63405-85-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study completion date - 06 October 1976.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Sodium 3-[[3-methoxy-4-[(4-methoxyphenyl)azo]phenyl]azo]benzenesulphonate
- EC Number:
- 264-129-6
- EC Name:
- Sodium 3-[[3-methoxy-4-[(4-methoxyphenyl)azo]phenyl]azo]benzenesulphonate
- Cas Number:
- 63405-85-6
- Molecular formula:
- C20H18N4O5S.Na
- IUPAC Name:
- sodium 3-({3-methoxy-4-[(4-methoxyphenyl)diazenyl]phenyl}diazenyl)benzenesulfonate
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- None
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: The rabbits were housed individually in suspended, wire-bottomed cages and maintained on a standard laboratory.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: All rabbits had been maintained under observation in the laboratory for at least seven days prior to testing.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Details on dermal exposure:
TEST SITE
- Area of exposure: Twenty-four hours prior to the dermal applications, the backs of the rabbits were shaved free of hair with electric clippers.
- % coverage: The shaved area on each animal constituted about 30 percent of the total body surface area.
- Type of wrap if used: The test site was covered by wrapping the trunk of the animal with impervious plastic sheeting which was securely taped in place
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: after 24 hours- Duration of exposure:
- 24 hours
- Doses:
- 3000 mg/kg body weight
- No. of animals per sex per dose:
- 4 animals/dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology - Statistics:
- No statistical analysis was used.
Results and discussion
- Preliminary study:
- None
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred during the study
- Clinical signs:
- No clinical signs were observed during the course of the study.
- Body weight:
- The body weights were recorded on day 0, 7 & 14 of the test.
- Gross pathology:
- No macroscopic findings were observed at necropsy.
- Other findings:
- None
Any other information on results incl. tables
Mortality & Body Weight Data:
Dose level (mg/kg) | Animal Number & Sex | Individual Body Weights (kg) | Number Dead | Percent Dead | |||
0 | 7 | 14 | Number Tested | ||||
3,000 | 1 - M* | 2.7 | 2.88 | 3.02 | 0/4 | 0 | |
2 - M | 2.7 | 3.08 | 3.08 | ||||
3 - F* | 2.8 | 3.1 | 3.1 | ||||
4 - F | 2.68 | 2.86 | 2.86 |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose of FAT 20004 after single dermal administration to rabbits of both sexes, observed over a period of 14 days is: LD50 (rabbit): >3000 mg/kg body weight.
- Executive summary:
A key study was performed to determine the acute dermal toxicity of FAT 20004 on New Zealand rabbits over a period of 14 days. The test substance was applied at a dose of 3000 mg/kg body weight. The test site was covered by wrapping the trunk of the animal with impervious plastic sheeting which was securely taped in place. The test material remained in contact with the skin for 24 hours. At the end of this period, the plastic sheeting and all residual test material were removed. The test sites were examined for local skin reactions and the animals were returned to their cages. Observations for mortality, local skin reactions, and behavioral abnormalities were continued for a total of 14 days following the skin applications. Initial, 7 and 14-day body weights were recorded. A necropsy examination was conducted on all animals. No pharmacotoxic symptoms were observed in the rabbits following dermal exposure to FAT 20004. The material stained the skin of the albino rabbit. Due to this, skin reactions (erythema or burns) at 24 hours could not be evaluated. No skin changes were noted at 7 and 14 days. Necropsy examination did not reveal any gross pathologic alterations. The median lethal dose of FAT 20004 after single dermal administration to rabbits of both sexes, observed over a period of 14 days is: LD50 (rabbit): >3000 mg/kg body weight.
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