Registration Dossier
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EC number: 242-362-4 | CAS number: 18479-58-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitization
In three well conducted and documented key studies in human volunteers (Section 7.10.4), concentrations of 5% to 20% of the analogue chemicals, dimyrcetol or myrcenol, dihydro derivative, applied to skin were neither irritating nor sensitizing to the skin. In a key human repeated-insult patch test (HRIPT), 20% myrcenol, dihydro derivative, was applied under occlusive patch for 24 -hour periods to the upper backs of 99 test subjects on 3 days/week for a total of 9 applications. After an approximately 2 -week rest period, fresh challenge patches were applied to previously untreated areas on the backs of the test subjects. Under the conditions of this study, the test material failed to produce either dermal irritation or sensitization. In a similarly conducted study, dimyrcetol failed to produce dermal irritation or sensitization at concentrations of 10% (107 test subjects) or at a concentration of 5% (110 test subjects). In a Human Maximization Test in 25 volunteers, dimyrcetol (4%) was applied as occlusive patches to the volar forearms or backs for alternate-day 48 -hour periods. Patch sites were pretreated with 2.5% aqueous SLS under occlusion (24 hours). Following a 10 -day rest period, challenge patches were applied. Dimyrcetol under the conditions of this study did not produce contact sensitization. In a Local Lymph Node Assay (LLNA) in mice, dimyrcetol at concentrations of 0.5% to 25% w/v, failed to produce a 3 -fold or greater increase in lymphoctye proliferation and was rated as unlikely to be a skin sensitizer.
Please refer to Section 13 of this IUCLID file for read-across documentation and rationale for the selection of representative analogue chemicals.
Migrated from Short description of key information:
Human repeated insult patch tests with analogue chemicals at concentrations up to 20% failed to produce either dermal irritation or sensitization.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
No information identified
Justification for classification or non-classification
Dihydromyrcenol would not be considered a skin sensitizer based on the results of human repeated insult patch tests with the surrogate materials dimyrcetol or myrcenol, dihydro derivative, at concentrations as high as 20%. In addition, dimyrcetol failed to produce a positive response in the mouse LLNA test at a maximum concentration of 25%. Dihydromyrcenol would not be classified for contact sensitization under the EU DSD criteria (EU Directive 67/548/EEC), the EU CLP (GHS) criteria (EU Regulation 1272/2008) or the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN-GHS)..
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