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EC number: 242-362-4
CAS number: 18479-58-8
Table 2: Skin absorption of dimyrcetol (% of applied dose, mean±SE, n=12) at 24 hours
dose: 127 µg/cm2
dose: 169 µg/cm2
dose: 296 µg/cm2
Stability of dimyrcetol solutions:
Dimyrcetol A appeared to permeate to a greater degree than dimyrcetol B. Approximately 20% of dimyrcetol B was observed to hydrolyze to dimyrcetol A in 24 hours from a solution containing 4 µg/mL (determined in a separate experiment). The rate of hydrolysis was not sufficient to fully explain the differences in permeation values.
Very rapid evaporative losses were recorded, with <10% recovered for both components after 1 hour form diffusion cells equipped with PTFE discs. No dimyrcetol was detectable in these cells after 6 hours. Dimyrcetol B evaporated more rapidly than dimyrcetol A (8.97% recovery at 1 hour), but neither component was detectable on PTFE surfaces at 2 hours.
Benzoic acid permeation:
The reference compound, benzoic acid, displayed a mean maximal absorption rate of approximately 29.8 µg/cm^2/h. This measured value is within the range of measurements reported in a multi-centre study (Van de Sandt et al., 2004).
The in vitro percutaneous absorption of dimyrcetol under in-use (unoccluded) conditions at an application concentration of 6% (w/v) in 70/30% (v/v) ethanol/water was determined in the current study. The absorption of each component, dimyrcetol A (2,6-dimethyl-7-octen-2-ol) and dimyrcetol B (2,6-dimethyl-7-octen-2-ol formate ester) were separately measured and combined for total dimyrcetol absorption.
Component A was observed to more rapidly permeate human skin than component B. In addition, component B was found to more rapidly evaporate than component A. Hydrolysis of dimyrcetol B to A was also an issue, and may have contributed to the overall observed absorption values.
The levels of dimyrcetol in the epidermis (with any remaining in stratum corneum after tape stripping), filter paper membrane supports and receptor fluids combined gave total absorbed doses of 2.50 +/- 0.20% and 0.662 +/- 0.040% for components A and B, respectively, and a combined value of 1.45 +/- 0.10%. Overall recoveries of dimyrcetol were low with values 3.18 +/- 0.21%, 1.74 +/- 0.29% and 2.36 +/- 0.24% of the applied dose for dimyrcetol A, B and combined, respectively. Evaporative losses were responsible for the low recoveries recorded.
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