Registration Dossier
Registration Dossier
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EC number: 242-362-4 | CAS number: 18479-58-8
Endpoint summary
Administrative data
Description of key information
Additional information
Results of the OECD 301B ready biodegradation test indicate that the test item is readily biodegradable: 72% degradation after 28 days. According to the REACH regulation, it was not necessary to conduct the following tests as the test item was determined to be readily biodegradable:
- Hydrolysis test
- Biodegradation in water and sediment: simulation test
- Biodegradation in soil
Adsorption/desorption: the adsorption coefficient of dihydromyrcenol was determined using the HPLC method. Under the conditions of study, the adsorption coefficient of the test item was 177.83 (log Koc = 2.25). This finding suggests that the test item will show limited binding to soil or sediment particulates.
Photodegradation in air: removal from the atmosphere by reaction in sunlight is predicted to be rapid (half-life due to reaction with atmospheric OH radicals or ozone 3.449 hours or 22.92 hours respectively, QSAR estimates)
Although the experimentally determined Log Kow of the test item is slightly greater than 3.0, low BCF (64.8 (L/kg ww or dimensionless) estimated by the BCFBAF v3.00 module of EPISuite v4.0) and rapid biotransformation in fish are predicted by application of the widely accepted EPISuite QSAR model to the test item. The prediction of rapid biotransformation is supported by analogy to mammalian metabolism data. Together, these results lead to low concern for possible bioaccumulation. In addition a similar BCF value can be derived using the BCF model mentioned in REACH guidance R.7.10.3.2, this results in a BCF value of 115 l/kg wwt. This somewhat higher value does not allow for metabolic transformation, which is modelled in the EPISuite QSAR calculation (and mammalian toxicokinetic data in this dossier support a prediction of such biotransformation).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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