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EC number: 242-362-4
CAS number: 18479-58-8
Table 2: Primary eye irritation data for individual animals and observation times
(A x B x 5)
A X 5
(A + B + C) x 2
(24,48 and 72 hr)
Mean by sample time =
In a study in rabbits, 0.1 mL of undiluted test item was applied to six rabbit eyes followed by examinations at 24-, 48 and 72-hours and at days 4 and 7 days following treatment. Eyes were examined with fluorescein stain under ultraviolet light at 24-hours and 7 days. Any persistent changes noted at day 7 were re-evaluated on day 10. All animals developed corneal opacity by 24 hours (scores of 1 to 2). Opacity had cleared in one animal at 72 hours and in 4 of 6 animals by day 7. The eyes of the last 2 animals cleared by day 10. Based on the Draize scoring system, the material would be rated as moderately irritating to eyes. Mean overall scores at 24-, 48- and 72-hours were as follows: opacity, 1.56; iris, 0.06; conjunctival redness, 1.44; conjunctival chemosis, 0.50; and conjunctival discharge, 0.56. In a supporting study in rabbits, undiluted dimyrcetol was rated an eye irritant based on the Draize scoring system. Mean overall scores at 24-, 48- and 72-hours were as follows: opacity, 0.33; iris, 0.17; conjunctival redness, 0.83; conjunctival chemosis, 0.56; and conjunctival discharge, 0.56. Under the conditions of this study, the test article was classified as moderately irritating to the eye of the albino rabbit.
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