2,6-dimethyloct-7-en-2-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Minimal experimental detail and documentation. Information available in a summary document only. Although studies were not conducted according to currently accepted protocols and did not follow GLP procedures, the studies followed acceptable procedures of the time and the results are valid.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Principles of method if other than guideline:

No information available.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Reaction mass of 2,6-dimethyloct-7-en-2-ol and 2,6-dimethyloct-7-en-2-yl formate

EC Number:

915-335-6

Molecular formula:

C11H20O2 C10H20O

IUPAC Name:

Reaction mass of 2,6-dimethyloct-7-en-2-ol and 2,6-dimethyloct-7-en-2-yl formate

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No information available.

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

No details available.

Doses:

2560, 3200, 4000 or 5000 mg/kg bw

No. of animals per sex per dose:

10

Control animals:

not specified

Details on study design:

No details available.

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

4 100 mg/kg bw

95% CL:

> 3 500 - < 4 800

Mortality:

See Table 1.

Clinical signs:

other: other: 2560 mg/kg bw: lethargy 3200 mg/kg bw: lethargy, piloerection, blood on nose 4000 mg/kg bw: lethargy, flaccid, ataxia 5000 mg/kg bw: diarrhea

Any other information on results incl. tables

 Table 1: Acute Oral Toxicity in the Rat - Mortality

 

Dose Levels (g/kg bwt)	Mortality, total	Day of Death
		0	1	2	3	6	9	11
2.56	1/10							1
3.2	3/10		2		1
4.0	4/10		2	1
5.0	8/10	1	5	2

 

Table 2: Acute Oral Toxicity in the Rat - Clinical Signs and Necropsy Findings

 

		Dose Levels (at death/sacrifice)
		2.56	2.56	3.2	3.2	4.0	4.0	5.0	5.0
Necropsy Observations		Death	Sacr	Death	Sacr	Death	Sacr	Death	Sacr
Normal			3		1
Exudate, nose/mouth						3		7
Lungs - dark				1
	white nodules					2
	dark areas			2	4		6	6	2
Liver - dark		1			1	1		4
	mottled		3			2	2	3
Kidneys - dark					2
	mottled		1
Skin - edema
	hairless
Intestines - red areas				2		3		6
	orange areas			1		1		1
Stomach - red areas				2	3
Spleen - large			2			2		1
	dark						1

 

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 value for dimyrcetol in the rat following oral gavage administration was 4100 mg/kg bw. Signs of toxicity described in some animals in this study included lethargy, piloerection, blood on the nose, flaccidity, ataxia, and diarrhea.

Executive summary:

The LD50 value for dimyrcetol in the rat following oral gavage administration was 4100 mg/kg bw. Signs of toxicity described in some animals in this study included lethargy, piloerection, blood on the nose, flaccidity, ataxia, and diarrhea.