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EC number: 203-806-2 | CAS number: 110-82-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- In Vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP status unknown, near guideline study, available as unpublished report, restrictions in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Deviation did not impact the scientific validity of the study.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclohexane
- EC Number:
- 203-806-2
- EC Name:
- Cyclohexane
- Cas Number:
- 110-82-7
- Molecular formula:
- C6H12
- IUPAC Name:
- cyclohexane
- Details on test material:
- Not reported
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Not reported
Test system
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- Not reported
- Duration of treatment / exposure:
- Not reported
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Remarks:
- cornea
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 2
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- overall irritation score
- Remarks:
- iris
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 0.8
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- overall irritation score
- Remarks:
- conjunctivae
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 2
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- overall irritation score
- Basis:
- other: total (cornea, iris and conjuctivae)
- Time point:
- other: 1 h
- Score:
- 3.7
- Reversibility:
- fully reversible within: 24 h
Any other information on results incl. tables
The report states that corneal opacity (involving up to 25% of the cornea) was noted in one rabbit and iritis in another 1 hr post-instillation however the rapid reversibility of these responses (both fully resolved by 24 hr) suggests possible over-interpretation. Conjunctival redness was also noted in 5 rabbits with conjunctival chemosis in one, however responses again cleared within 24 hours.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Conclusions:
- Slight eye irritation effects were present 1 hour after instillation but had resolved within 24 hours.
- Executive summary:
Slight eye irritation effects were present 1 hour after instillation but had resolved within 24 hours.
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