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Long-term toxicity to fish

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Description of key information

The calculated 21 day EL10 from TLM QSAR for Onchorynchus mykiss was 0.447 mg/L

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.447 mg/L

Additional information

The endpoint calculated is the HC5 - The narcosis Target Lipid model (TLM) is used to develop a species sensitivity distribution, from which the HC5 is calculated and covers aquatic organisms. The range of organisms (47 species) used in the training set are known and include plants, invertebrates and fish. The narcosis target lipid model was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms. The TLM is used to derive the predicted-no-effect concentrations (PNECs) using the hazardous concentration to 5% species (HC5) statistical extrapolation procedure.

The approach describes:

•       The theory and how to predict the acute toxicity to these organisms;

•       Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points; and

•       Statistical analysis and conversion into an HC5.