Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-806-2 | CAS number: 110-82-7
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 44.7 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 9 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 4.47 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 0.9 µg/L
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 3.24 mg/L
- Assessment factor:
- 1
- Extrapolation method:
- sensitivity distribution
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 3.6 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.36 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.694 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Although measured acute toxicity data is available for fish, invertebrates and algae the HC5 QSAR equation was selected to calculate the PNEC. The reason for selecting this approach to calculate the PNEC is because the equation was generated using data measured data for over 1000 hydrocarbon chemical structures and represents a more holistic evaluation of hydrocarbons’ fate and behaviour and toxicity in the environment.
Conclusion on classification
Cyclohexane has a harmonised classification of Acute Category 1 and Chronic Category 1.
An acute dataset is available for cylochexane and the lowest acute reported result was a 48 hour EC50 for Daphnia magna of 0.9 mg/L A chronic dataset is not available for cyclohexane but a 72 hour NOEC for algae is available which reports a value of 0.925 mg/L.
The results would indicate that cyclohexane would not meet the criteria for toxic in the PBT assessment. The results would meet the criteria for Acute Category 1, with the phrase H400: very toxic to aquatic life. As cyclohexane is considered to be readily biodegradable, the results would meet the criteria for Chronic Category 3, with the phrase H412: harmful to aquatic life with long lasting effects. These have been included in the dossier as a self-classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
