Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 287-494-3 | CAS number: 85536-14-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The potential for dermal irritation was examined in a study on the test substance. The shaved backs of three male and three female rabbits were exposed for 4 hours to 0.5 ml of the LAB Sulfonic Acid and observed for up to 14 days. Significant reddening was observed throughout at least day 9. Swelling was perceptible throughout and appeared to become more noticeable with time. Bloody wounds and scar formation were observed through at least observation day 9. The test substance is considered highly irritating to the skin of rabbits. The primary dermal irritation index was 5.25 (mean of 1, 24, 48 and 72 hours). In another study, the test article was applied at a dose of 0.5 mL to three skin sites on a clipped area of each of six albino rabbits. The three sites were designated for application of test article as follows; Site A - three minute occluded contact, Site B - one hour occluded contact, and Site C - four hour occluded contact. Three minute occluded contact produced minimal irritation, and necrosis was not observed in any of the six test subjects. The test article is not corrosive following a three minute contact period. One hour occluded contact produced severe irritation, and necrosis was observed in five of the six test subjects. The test article is corrosive following a one hour contact period. Based on this information, the test substance is considered a Category 1B irritant/corrosive according to CLP guidelines based on persistent irritation (H314: Causes severe skin burns and eye damage).
The potential for irritation to eyes was examined in a study on the test substance. The eyes of six rabbits were treated with LAB Sulfonic Acid and observed for six days. Treatment was to the right eye with lower lid removed. The left eye was untreated and served as the control. The eyes were not washed out during the test. Observations were made at 1, 24, 48, and 72 hours and at 6 days after application. Results indicate that the substance was moderately irritating but because of the intensity of the necrosis formation the study was stopped at day 6. According to these results, the test substance is a category 1 eye irritant according to CLP because it caused damage that was not reversible within the 6 days of the study (H318: Causes serious eye damage).
LAB Sulfonic Acid is corrosive to the skin
and eyes at a 100% undiluted, unrinsed dose and is classified under the
CLP as category 1B for skin, and category 1 for eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Laboratory study in experienced testing laboratory.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Male and female white New Zealand rabbits weight between 4 and 5.6 kg each. Animals were marked with a 5 digit number and held in steel cages. They were acclimated for 14 days prior to testing. Standard rabbit diet and water was provided ad libitum. Room temperature was held at 20 degrees C +/- 1 degree C, humidity at 60 +/- 5%, with a 12/12 hour light/dark cycle.
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Observations were made after 1, 24, 48, 72 hours and 6, 9, and 14 days.
- Number of animals:
- 6 (3 male, 3 female)
- Details on study design:
- The shaved treated area (about 6 m2) was covered with gauze and covered by polyethylene film for the first 4 hours, at which time the test area was rinsed with warm water. Observations were made after 1, 24, 48, 72 hours and 6, 9, and 14 days.
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: Mean of 1, 24, 48 and 72 hours.
- Score:
- 5.25
- Max. score:
- 6
- Reversibility:
- not reversible
- Remarks on result:
- other: highly irritating
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hr readings
- Score:
- 5.33
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 14 days
- Other effects:
- Significant reddening effects were observed at all times and were persistent. Bloody wounds and scar formation were observed through at least observation day 9.
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- Result: Highly irritating
- Executive summary:
The shaved backs of three male and three female rabbits were exposed for 4 hours to 0.5 ml of the test substance and observed for up to 14 days. Significant reddening was observed throughout at least day 9. Swelling was perceptible throughout and appeared to become more noticeable with time. Bloody wounds and scar formation were observed through at least observation day 9. The test substance is considered highly irritating to the skin of rabbits. The test substance is considered corrosive to skin according to OECD GHS guidelines.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1992
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Department of Transportation, Method of Testing Corrosion to Skin. Federal Register, Vol. 41, No. 118, Sept. 27, 1976, p.42572.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: 49 Code of Federal Regulations, part 173, Appendix A, Dec. 31, 1991, pp. 594, 595, and 471. Part 171, Dec. 19, 1994.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kuiper Rabbitry, Gary, Indiana
- Age at study initiation: 8 to 10 weeks
- Housing: The rabbits were individually housed in stainless steel cages in a temperature, humidity, and light controlled room. The rabbits were maintained according to the recommendations contained in the National Academy Press 1996: "Guide for the Care and Use of Laboratory Animals".
- Diet: Purina Rabbit Chow, ad libitum
- Acclimation period: At least three days - Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL test article - Duration of treatment / exposure:
- For 3 minutes (site A), 1 hour (site B) and 4 hours (site C)
- Observation period:
- Up to 14 days
- Number of animals:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: Performed by wiping .
- Time after start of exposure: At the conclusion of the contact periods.
OBSERVATION TIME POINTS
Observations for irritation, ulceration and necrosis were performed and findings recorded at the end of each contact period, again at 60 minutes for the 3 minute contact and also at 24, 48, and 72 hours following test article application for the 1 and 4 hour contacts. Additional readings were continued up to 14 days to confirm Packing Group.
SCORING SYSTEM:
- Method of calculation: Corrosion is considered to have resulted if the substances in contact with the rabbit skin, produced full thickness destruction or irreversible alteration of the tissue. Tissue destruction is considered to have occurred if. at any of the readings there is ulceration and/or necrosis. Tissue destruction would not include merely sloughing of the epidermis, erythema, oedema or fissuring. Scoring was performed according to the scoring schemes presented in Tables 1 to 3 in the "Any other information on materials and methods incl. tables" field. - Irritation parameter:
- erythema score
- Remarks:
- Site A - 3 minutes of exposure
- Basis:
- mean
- Remarks:
- Animal #1 to #6
- Time point:
- other: 1 hour
- Score:
- 0.5
- Max. score:
- 4
- Remarks on result:
- other:
- Remarks:
- No necropsy observed
- Irritation parameter:
- erythema score
- Remarks:
- Site B - 1 hour of exposure
- Basis:
- mean
- Remarks:
- Animal #1 to #6
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Remarks on result:
- other:
- Remarks:
- Necropsy observed in 5 out of 6 animals.
- Irritation parameter:
- erythema score
- Remarks:
- Site C - 4 hours of exposure
- Basis:
- mean
- Remarks:
- Animal #1 to #6
- Time point:
- 72 h
- Score:
- 4
- Max. score:
- 4
- Remarks on result:
- other:
- Remarks:
- Necropsy observed in all animals.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Other time points were assessed for classification purposes for corrosive chemicals.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Remarks:
- Other time points were assessed for classification purposes for corrosive chemicals.
- Irritant / corrosive response data:
- Three minute occluded contact produced minimal irritation, and necrosis was not observed in any of the six test subjects. The test material is not corrosive following a three minute contact period. One hour occluded contact produced severe irritation, and necrosis was observed in five of the six test subjects. The test material is corrosive following a one hour contact period.
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- In accordance with D.O.T. Guidelines, Federal Register, Volume 55, No. 246, the test substance is a corrosive agent and would be classified as packing group II.
- Executive summary:
The test article was tested for corrosivity in accordance with Department of Transportation Guidelines. The test article was applied at a dose of 0.5 mL to three skin sites on a clipped area of each of six albino rabbits. The three sites were designated for application of test article as follows; Site A - three minute occluded contact, Site B - one hour occluded contact, and Site C - four hour occluded contact.
Three minute occluded contact produced minimal irritation, and necrosis was not observed in any of the six test subjects. The test article is not corrosive following a three minute contact period. One hour occluded contact produced severe irritation, and necrosis was observed in five of the six test subjects. The test article is corrosive following a one hour contact period.
In accordance with D.O.T. Guidelines, Federal Register, Volume 55, No. 246, the sample is a corrosive agent and would be classified as packing group II.
Referenceopen allclose all
Results of Skin Irritation Study in Rabbits
Observation |
Endpoint |
Male 11499 |
Male 11887 |
Male 11901 |
Female 11580 |
Female 11658 |
Female 11802 |
1 hr |
Erythema |
4 X |
4 X |
4 X |
4 X |
4 X |
4 X |
1 hr |
Edema |
1 |
1 |
1 |
1 |
1 |
1 |
24 hrs |
Erythema |
4 X |
4 X |
4 X |
4 X |
4 X |
4 X |
24 hrs |
Edema |
1 |
1 |
1 |
1 |
1 |
1 |
48 hrs |
Erythema |
4 X |
4 X |
4 X |
4 X * |
4 X |
4 X * |
48 hrs |
Edema |
1 |
1 |
1 |
1 |
1 |
1 |
72 hrs |
Erythema |
4 * |
4 * |
4 X * |
4 X * |
4 * |
4 * |
72 hrs |
Edema |
2 |
2 |
2 |
2 |
2 |
2 |
6 days |
Erythema |
4 + |
4 * |
4 * |
4 * - |
4 + |
4 + - |
6 days |
Edema |
2 |
2 |
2 |
2 |
2 |
2 |
9 days |
Erythema |
W |
W |
W |
+ |
W |
+ |
9 days |
Edema |
C N |
C N |
N |
|
N |
W |
14 days |
Erythema |
N |
N |
N |
N |
N |
N |
14 days |
Edema |
N |
N |
N |
N |
N |
N |
X ¿ Necrosis in application area bordered by swelling
* - Application area hardened
+ - Wavy crust
- - Application area paper-like
W ¿ Bloody wounds
C - Crust formation
N ¿ Scar formation
Table 1. Site A, Erythema scores- Contact time: 3 minutes
ANIMAL NUMBER |
3 Minutes |
1 Hour |
1 | 0 | 1 |
2 | 0 | 1 |
3 | 0 | 0 |
4 | 0 | 0 |
5 | 0 | 1 |
6 | 0 | 0 |
Table 2. Site B, Erythema scores- Contact time: 1 hour
ANIMAL NUMBER |
1 Hour |
Day 1 | Day 2 | Day 3 |
1 | 2 | 3 | 4 | N |
2 | 2 | 3 | 4 | N |
3 | 2 | 4 | 4 | N |
4 | 2 | 4 | 4 | N |
5 | 1 | 3 | 4 | N |
6 | 2 | 3 | 4 | 4 |
Table 3. Site C, Erythema scores - Contact time: 4 hours
ANIMAL NUMBER |
4 Hours |
Day 1 |
Day 2 |
Day 3 |
1 | 4 | 4 | 4 | N |
2 | 4 | 4 | N | N |
3 | 4 | 4 | N | N |
4 | 4 | 4 | N | N |
5 | N | N | N | N |
6 | 4 | N | N | N |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Laboratory study in experienced laboratory.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Male and female white New Zealand rabbits weight between 3.7 and 6.0 kg each. Animals were marked with a 5 digit number and held in steel cages. They were acclimated for 14 days prior to testing. Standard rabbit diet and water was provided ad libitum. Room temperature was held at 20 degrees C +/- 1 degree C, humidity at 60 +/- 5%, with a 12/12 hour light/dark cycle.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL
- Duration of treatment / exposure:
- Single treatment that was not washed out.
- Observation period (in vivo):
- 1, 24, 48, and 72 hours and at 6 days after application.
- Number of animals or in vitro replicates:
- 6 (3 male, 3 female)
- Details on study design:
- Treatment was to the right eye with lower lid removed. The left eye was untreated and served as the control. The eyes were not washed out during the test. Observations were made at 1, 24, 48, and 72 hours and at 6 days after application.
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, and 72 hrs and 6 days
- Score:
- 46.9
- Reversibility:
- not fully reversible within: 6 days
- Remarks on result:
- other: moderately irritating
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, #2, #6
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 6 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 6 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 6 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 3.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 6 days
- Irritation parameter:
- iris score
- Basis:
- animal: #1 to #6
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 6 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- Redness
- Basis:
- animal: #1 to #6
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 6 days
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1 and #5
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 6 days
- Irritation parameter:
- chemosis score
- Basis:
- animal: #2, #3, #4
- Time point:
- 24/48/72 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 6 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 2.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 6 days
- Irritant / corrosive response data:
- Results indicated a moderate irritancy, but because of the intensity of the necrosis formation, the study was stopped at day 6.
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Result: moderately irritating
- Executive summary:
The eyes of six rabbits were treated with the test substance and observed for six days. Results indicate that the substance was moderately irritating but because of the intensity of the necrosis formation the study was stopped at day 6.
Reference
Results of Eye Irritation Study in Rabbits
Observation |
Endpoint |
Male 11655 |
Male 11715 |
Male 11771 |
Female 11798 |
Female 11804 |
Female 11838 |
1 hr |
Cornea ¿ degree |
1 |
1 |
2 |
2 |
2 |
1 |
1 hr |
Cornea ¿ range |
4 |
4 |
4 |
4 |
4 |
4 |
1 hr |
Iris |
1X |
1X |
1X |
1X |
1X |
1X |
1 hr |
Conjunctiva ¿ redness |
3N |
3N |
3N |
2N |
3N |
3N |
1 hr |
Conjunctiva ¿ edema |
1 |
1 |
1 |
1 |
2 |
2 |
1 hr |
Conjunctiva - exsudation |
3 |
3 |
3 |
3 |
3 |
3 |
24 hrs |
Cornea -degree |
1 |
1 |
2 |
2 |
3C |
1 |
24 hrs |
Cornea ¿ range |
4 |
4 |
4 |
4 |
2 |
4 |
24 hrs |
Iris |
1* |
1* |
1* |
1* |
1*- |
1* |
24 hrs |
Conjunctiva ¿ redness |
3N |
3N |
3N |
3N |
3N S |
3N |
24 hrs |
Conjunctiva ¿ edema |
2 |
2 |
2 |
2 |
2 |
3 |
24 hrs |
Conjunctiva - exsudation |
2 |
2 |
2 |
2 |
2 |
2 |
48 hrs |
Cornea ¿ degree |
1 |
1 |
2 |
2 |
3C |
1 |
48 hrs |
Cornea - range |
4 |
4 |
4 |
4 |
2 |
4 |
48 hrs |
Iris |
1* |
1* |
1* |
1* |
1*- |
1* |
48 hrs |
Conjunctiva ¿ redness |
3N S |
3N |
3N S |
3N S |
3N S |
3N S |
48 hrs |
Conjunctiva ¿ edema |
2 |
1 |
1 |
1 |
2 |
3 |
48 hrs |
Conjunctiva - exsudation |
2 |
2 |
2 |
2 |
2 |
2 |
72 hrs |
Cornea ¿ degree |
1 |
1 |
1 |
2 |
4C |
1 |
72 hrs |
Cornea - range |
4 |
2 |
4 |
4 |
2 |
4 |
72 hrs |
Iris |
1X |
1X |
1* |
1* |
1*- |
1* |
72 hrs |
Conjunctiva - redness |
3N S |
3N S |
3N S |
3N S |
3N S |
3N S |
72 hrs |
Conjunctiva ¿ edema |
2 |
2 |
2 |
2 |
2 |
2 |
72 hrs |
Conjunctiva - exsudation |
2 |
2 |
2 |
2 |
2 |
2 |
6 days |
Cornea ¿ degree |
2 |
2 |
2 |
2 |
4C |
2 |
6 days |
Cornea -range |
3 |
3 |
2 |
3 |
2 |
4 |
6 days |
Iris |
1X |
1X |
1* |
1* |
1*- |
1* |
6 days |
Conjunctiva - redness |
3N S L |
3N L |
3N L H |
3N S L |
3N S L |
3N S L |
6 days |
Conjunctiva ¿ edema |
2 |
2 |
2 |
2 |
2 |
2 |
6 days |
Conjunctiva - exsudation |
2 |
1 |
2 |
2 |
2 |
2 |
C ¿ Cornea cloudy
X ¿ Parts of the iris turned red
* - Iris turned red
- - Retarded iris reaction
N ¿ Necrosis and corrosion of the conjunctiva
S ¿ Secretion formation
L ¿ Lids became encrusted
H ¿ Holding head inclined
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
LAB Sulfonic Acid was tested and found to be irritating to both the skin and eyes of test animals. In skin, One hour occluded contact produced severe irritation, and necrosis was observed in five of the six test subjects. The test article is corrosive following a one hour contact period. The test substance is considered highly corrosive to the skin of rabbits. In eyes, LAB Sulfonic Acid was moderately irritating but because of the intensity of the necrosis formation the study was stopped at day 6. According to these results, the test substance is classified as CLP category 1B for skin irritation (H314: Causes severe skin burns and eye damage) and CLP category 1 for eye irritation (H318: Causes serious eye damage).
Justification for selection of skin
irritation / corrosion endpoint:
Key studies are reliable without restriction, report in vivo
experimental results from 2 studies.
Justification for selection of eye irritation endpoint:
Key study is reliable without restriction, reports in vivo
experimental results.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Undiluted LAB Sulfonic Acid was tested and found to be corrosive to both the skin and eyes of test animals.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
