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EC number: 287-494-3 | CAS number: 85536-14-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- The cytogenetic studies and dominant lethal tests of long term administration with butylated hydroxytoluene (BHT) and linear alkylbenzene sulfonate (LAS) in mice and rats.
- Author:
- Masubuchi, M, Takahashi, A, Takahashi, O and Hiraga, K
- Year:
- 1 976
- Bibliographic source:
- Masubuchi et. al.,1976. The cytogenetic studies and dominant lethal tests of long term administration with butylated hydroxytoluene (BHT) and linear alkylbenzene sulfonate (LAS) in mice and rats. Ann. Rep. Tokyo Metrop. Res. Lab. Public Health, 27, 100-4.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A group of 7 male mice was fed a diet containing 0.6% test substance for 9 months. At the end of this period, the animals were each mated with two untreated females. On day 13 of pregnancy, the females were sacrificed, and the ovaries and uteri were examined.
- GLP compliance:
- no
- Type of assay:
- rodent dominant lethal assay
Test material
- Reference substance name:
- Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts
- EC Number:
- 270-115-0
- EC Name:
- Benzenesulfonic acid, C10-13-alkyl derivs., sodium salts
- Cas Number:
- 68411-30-3
- Molecular formula:
- Not applicable for UVCB
- IUPAC Name:
- sodium 4-undecylbenzenesulfonate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: JCL-ICR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CLEA Japan, Inc.
- Age at study initiation: 4 weeks
- Housing: individually, except during breeding
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25 ± 1
- Humidity (%): 55 ± 5
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: feed
- Details on exposure:
- DIET PREPARATION
- Mixing appropriate amounts with: feed powder CE-2 - Duration of treatment / exposure:
- 9 months
- Frequency of treatment:
- daily
Doses / concentrations
- Dose / conc.:
- 300 mg/kg bw/day (nominal)
- Remarks:
- 0.6% in diet
- No. of animals per sex per dose:
- 7
- Control animals:
- yes
Examinations
- Statistics:
- Rohrborn's method.
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Negative controls validity:
- valid
- Additional information on results:
- There were no significant differences in fertility, the mortality of ova and embryos, the number of surviving fetuses, or the index of dominant lethal induction between the experimental groups and the control group.
Any other information on results incl. tables
Dominant Lethal Assay Results
|
0.6% in Diet |
Control |
Number of mating females |
14 |
18 |
Number pregnant |
11 |
12 |
No. with dead embryos |
6 |
10 |
Dead embryos per pregnant female |
54.6% |
83.3% |
No. of corpora lutea |
156 |
161 |
Corpora lutea per pregnant female |
14.2 |
13.4 |
No. of implants |
148 |
156 |
Implants per pregnant female |
13.5 |
13.0 |
Implants per corpora lutea |
94.9 |
96.9 |
No. of live fetuses |
142 |
143 |
Live fetuses per pregnant female |
12.9 |
11.9 |
Live fetuses per corpora lutea |
91.0 |
88.8 |
Live fetuses per total implants |
96.0 |
91.7 |
No. of early dead fetuses |
4 |
12 |
No. of late dead fetuses |
2 |
1 |
% of dominant lethals |
-4.67 |
- |
% of dominant lethals |
-8.33 |
- |
Applicant's summary and conclusion
- Conclusions:
- The test substance did not cause genetic disorders in mice.
- Executive summary:
A group of 7 male mice was fed a diet containing 0.6% test substance for 9 months. At the end of this period, the animals were each mated with two untreated females. On day 13 of pregnancy, the females were sacrificed, and the ovaries and uteri were examined. No increase in dominant lethal induction was seen as compared to controls. The test substance does not cause genetic disorders.
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