Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-11-13
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): n-Butyraldehyde
- Substance type: organic
- Physical state: liquid
- Analytical purity: GC purity 99.7%
- Impurities (identity and concentrations): Iso-butyraldehyde: 0.05%, Butanoic acid: 0.10%
- Lot/batch No.:P9266

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
1.3
Temp.:
20 °C
pH:
> 4.4 - < 4.7
Details on results:
Flask Log Pow
1:1 1.26
1:2 1.25
2:1 1.25

Any other information on results incl. tables

Analysed results with HPLC

Flask

Water phase

n-octanol phase

1:1

0.028 mg/ml

0.511 mg/ml

1:2

0.018 mg/ml

0.316 mg/ml

2:1

0.029 mg/ml

0.518mg/ml

pH results

Flask

pH in water phase

1:1

4.7

1:2

4.6

2:1

4.4

Log Pow

Flask

Log Pow

1:1

1.26

1:2

1.25

2:1

1.25

Applicant's summary and conclusion

Conclusions:
Log Pow 1.3
Executive summary:

Log Pow 1.3