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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given, comparable to guideline study, limited documentation
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1951
Report Date:
1951

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
other: Screening based on standard methods
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No information provided

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
male/female
Details on test animals and environmental conditions:
No information provided

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
No information provided
Doses:
no data, probably logarithmic scale (from Smyth et al., Arch. Ind. Hyg Occup. Med 10, 61-68 (1954)
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
No information provided
Statistics:
LD50 according to Thompson 1947 (from Smyth et al. J. Ind. Hyg. Toxicol. 31, 60-62 (1949))

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 5 890 mg/kg bw
Based on:
test mat.
Remarks on result:
other: SD: 5540 mg/kg bw - 6250 mg/kg bw
Mortality:
No information provided.
Clinical signs:
No further information
Body weight:
No information provided
Gross pathology:
No information provided
Other findings:
No further information

Any other information on results incl. tables

No additional information

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
GHS: no category (>5000 mg/kg)
Executive summary:

In an early screening test, an approximate oral LD50 in male and female rats was determined to be 5890 mg/kg bw (SD: 5540 mg/kg bw - 6250 mg/kg bw). The result was obtained within a comprehensive screening testing programme on short-term toxic effects. Results are only documented as toxicity values in tabular form without details on acute adverse effects. Within this scope of restriction and irrespective of the study age, the data is considered reliable.