Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-820-0 | CAS number: 74-89-5
Signs of Phytotoxicity evaluated by Microscopic Observations:
The microscopic examination of the shape of the algal cells after 72 hours of test duration did not show any difference between the algae that had been growing up to the highest nominal test concentration of 700 mg test item/L and the algal cells in the control. Thus, the shape of the algal cells was not obviously affected up to this test concentration, the highest concentration tested
The influence of Methylamine (aqueous solution 40 %) on the growth of the freshwater green algae Desmodesmus subspicatus was assessed in a static concentration-response test. The 72-hour EyC50 was calculated to be 116 mg test item/L (46.7 mg a.i./L) and the 72-hour ErC50 value was calculated to be > 700 mg test item/L (> 281 mg a.i./L). The 72-hour NOEC for yield and growth rate was determined to be 22.2 mg test item/L (8.9 mg a.i./L) and the associated 72-hour LOEC for yield and growth rate was determined to be 70.1 mg test item/L (28.2 mg a.i./L).
All reported results refer to nominal values since the concentrations of the test item were within ± 20% of the nominal concentrations during the test.
EC50(72h; endpoint: growth rate) > 281.8 mg active ingredient/L for Desmodesmus subspicatus (OECD 201)
EC10(72h; endpoint: growth rate) 20.5 mg active ingredient/L for Desmodesmus subspicatus (OECD 201)
NOEC(72h; endpoint: growth rate) 8.9 mg active ingredient/L for Desmodesmus subspicatus (OECD 201)
The effects of methylamine (40 % aqueous solution) on Desmodesmus subspicatus were investiged by Siche, O. and Wydra, V. (2020). The following nominal values (based on growth rate) were determined: EC50 (72h) > 281.8 mg active ingredient/L; EC20 (72 h) = 60.8 mg active ingredient/L; EC10 (72 h) = 20.5 mg active ingredient/L, a LOEC (72h) = 28.2 mg active ingredient/L and a NOEC (72 h) = 8.9 mg active ingredient/L. Furthermore, the following values based on yield were reported: EC50 (72h) = 46.7 mg active ingredient/L; EC20 (72 h) = 20.5 mg active ingredient/L; EC10 (72 h) = 11.9 mg active ingredient/L, a LOEC (72 h) = 28.2 mg active ingredient/L and a NOEC (72 h) = 8.9 mg active ingredient/L. All reported results refer to nominal values since the concentrations of the test item were within ± 20% of the nominal concentrations during the test.
In addition, there is a supporting QSAR calculation available. The result is an estimation by Ecosar v1.11 using an extensive set of structure-activity relationships (SARs). The substance methylamine is classified as 'Aliphatic Amine'. The EC50 estimated for green algae is 43 mg/L. This value is significantly lower than the experimentally determined value in a test according to OECD 201 and 23.
Furthermore, there is supporting information available. The information is, however, derived of older non guideline publications. In one investigation, the test organism was Selenastrum capricornutum (new name: Pseudokirchnerella subcapitata). 21% growth inhibition at 1mM (31 mg/L) was investigated. This experimental data was published by Andreozzi et.al.(2000). This value is in line with the reported values of the new key study (EC20 = 20.5 mg/L versus EC21 = 31 mg/L).
Last but not least, Scenedesmus obliquus was investigated to evaluate the toxicity of monomethylamine by Abeliovich, A. and Azov, A. in 1974. The scientists investigated the effects on the assimilation rate compared to controls at different pH values. The test concentration was chosen to be 160 mg/L. At a pH of 7.9 an 35 % increase can be investigated, whereas inhibition of 20 % and 97 % are given at pH values of 8.3 and 9.0, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again