Registration Dossier

Administrative data

Description of key information

The data of irritation potential of methylamine are waived from the acute toxicity studies (see 7.2.1. Acute toxicity oral, BASF-Test and 7.2.2. Acute toxicity inhalation, BASF-Test, Acute toxicity dermal: Goffman and Maguire, 1980).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Monomethylamine caused eye, nose and throat irritation if inhaled. Administered orally to the rats, methylamine was corrosive to stomach. Liquefied methylamine (or in contact with moist skin) caused necrosis in the guinea pigs skin which was evident for histological evaluation after 48 hours. In concentrations of 141 ppm a 50 % decrease of the respiratory rate in rats was found (Gagnaire etal., 1989).


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Effects on respiratory irritation: irritating

Justification for classification or non-classification

Classification & Labeling:

Monomethylamine (aqueous solution) is classified according to GHS as: Skin Corr. 1B, H314: Causes severe skin burns and eye damage

Monomethylamine (gaseous form) is classified according to GHS as: Skin Irrit. 2 , Eye damage 1, H315: Causes skin irritation, H318: Causes serious eye damage