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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer reviewed data
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
no
Analytical monitoring:
no
Test organisms (species):
Leuciscus idus
Test type:
static
Water media type:
freshwater
Total exposure duration:
48 h
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
16 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: not neutralized
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
970 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: neutralized
Validity criteria fulfilled:
yes
Executive summary:

In this experiment the toxicity of methylamine to fish conducted according to OECD guidelines (OECD 203) was tested. The mortality of Leuciscus idus after 48 h was tested in neutralized (LC50: 970 mg/l) and not neutralized (LC50: 16 mg/l) test substance solutions (Bayrisches Landesamt fuer Wasserwirtschaft 1986).

Description of key information

The results of the short-term toxicity studies indicate that MMA has a rather low or no noteworthy toxicity potential towards fish and does not have to be classified or labelled as acutely harmful to fish (no classification or labelling for Aquatic toxicity).

Key value for chemical safety assessment

Additional information

One key study on the toxicity of methylamine to fish conducted according to OECD guidelines (OECD 203) is available. The mortality of Leuciscus idus after 48 h was tested in neutralized (LC50: 970 mg/L) and not neutralized (LC50: 16 mg/L) test substance solutions (Bayrisches Landesamt fuer Wasserwirtschaft 1986).

Embryogenesis of Brachydanio rerio (Zebra fish) after expopsure to methylamine was investigated by Groth et.al. (1993; eggs was observed microscopically for 96 hours beginning with the 8 cell stage. Groth et al. (1993) determined no induction of any malformations and hatched embryos developed normally (NOEC: 3 mM = 93 mg/L, LC50: 22.9 mM = 711 mg/L).

Furthermore, Tonogai et al. investigated 1982 Oryzias latipes according to JIS K0102 (methylamine was neutralized using HCl) and found a LC50 (48h) of 1000 mg/L.

A QSAR performed by BASF (2019) came to the result of an LC50 (96h) of ray-finned fish (Actinopterygii) of 398 mg/L.

Kronauer et al. (1990) reported that 0.1 - 5 mg/mL incubation media (neutralized by HCl to pH 7.5) of MMA, caused mortality of most eggs by cytotoxic effects essentially at stage 24 of development. Malformations were not observed. The rate of embryonic mortality was 60% at 2 mg/mL. In a screening test focusing on the toxicity of methylamine toLeuciscus idus melanotusaLC50 > 500 mg/L was determined after 48 hours (BASF AG, 1977). However, detailed information on the test performance, e.g. neutralisation of the test substance, is not available.