Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
9.25 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
Overall assessment factor (AF):
1
Modified dose descriptor starting point:
NOAEC
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
9.25 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
Overall assessment factor (AF):
1
Dose descriptor:
NOAEC
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
Most sensitive endpoint:
acute toxicity

Workers - Hazard for the eyes

Additional information - workers

Due to the evaluated chemical physical properties of ethyl-2-cyanoacrylate, the test item cannot be classified as corrosive or explosive or as flammable but as irritant for safety reasons.Ethyl-2-cyanoacrylate shows a crystallisation at -71°C followed by a melting at -31°C. Under usual working conditions the very reactive monomer is a fluid, which polymerises in air or water due to the presents of moisture. Therefore it has to be kept in sealed apparatus to be processed. Ethyl-2-cyanoacrylate has no phyrophoric properties and cannot be classified as flammable. 

Irritation can occur through inhalation or contact to the eyes. But ethyl-2-cyanoacrylate has a low vapour pressure at ≤ 21 pascal and that will be reduces within second due polymerisation in presence of moisture

Based on human data an inhalation limit was derived at 1.8 ppm (9.25 mg/m3). In comparison with other justifications the German work exposure limit for the methyl-2-cyanoacrylate ester with a higher vapour pressure is set at 8 mg/m3. The Austrian MAK Commission set an acceptable workplace limit at 9 mg/m3.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
9.25 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
Overall assessment factor (AF):
1
Modified dose descriptor starting point:
NOAEC
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
9.25 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
Overall assessment factor (AF):
1
Dose descriptor:
NOAEC
Acute/short term exposure
Hazard assessment conclusion:
no data available: testing technically not feasible
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

Due to the evaluated chemical physical properties of ethyl-2-cyanoacrylate, the test item cannot be classified as corrosive or explosive or as flammable but as irritant for safety reasons. Ethyl-2-cyanoacrylate shows a crystallisation at -71°C followed by a melting at -31°C. Under usual working conditions the very reactive monomer is a fluid, which polymerises in air or water due to the presents of moisture. Therefore it has to be kept in sealed apparatus to be processed. Ethyl-2-cyanoacrylate has no phyrophoric properties and cannot be classified as flammable. 

Irritation can occur through inhalation or contact to the eyes. But ethyl-2-cyanoacrylate has a low vapour pressure at ≤ 21 pascal and that will be reduces within second due polymerisation in presence of moisture

Based on human data an inhalation limit was derived at 1.8 ppm (9.25 mg/m3). In comparison with other justifications the German work exposure limit for the methyl-2-cyanoacrylate ester with a higher vapour pressure is set at 8 mg/m3. The Austrian MAK Commission set an acceptable workplace limit at 9 mg/m3.