Registration Dossier

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Data waiving:
study technically not feasible
Justification for data waiving:
the study does not need to be conducted because direct and indirect exposure of the aquatic compartment to the substance is unlikely
other:
Justification for type of information:
Tests in aqueous or moist media with ethyl 2-cyanoacrylate cannot be performed due to technical reasons based on the chemical properties of the monomer. In presence of moisture ethyl 2-cyanoacrylate polymerises within seconds (inherent property of ethyl 2-cyanoacrylate based instant glues). The substance ethyl 2-cyanoacrylate (EC 230-391-5) is a representative of the group of cyanoacrylate based reactive glues. Colloquially this type of glues is named ‘instant glues’ indicating that they cure within seconds to minutes. The polymerisation reaction starts with the reaction of traces of hydroxide ions with the activated double bond and leads to insoluble polymers within very short periods of time. The concentration of hydroxide ions originating from the autoprotolysis of ambient moisture or adsorbed water on surfaces (COH- = 10-7 mol/L) is sufficient to start the polymerisation reaction. For details on the reaction of cyanoacrylates in presence of moisture and polymerisation reaction rates see chapter 5.6 Additional information on environmental fate and behaviour.

Data source

Materials and methods

Results and discussion

Bioaccumulation factor
Remarks on result:
other: study technically not feasible: Test substance polmerises on contact with water within seconds

Any other information on results incl. tables

Study technically not feasible → Tests in aqueous or moist media with ethyl 2-cyanoacrylate with the intent to determine effective concentrations or no effect concentrations cannot be performed due to technical reasons based on the chemical properties of the monomer. In presence of moisture ethyl 2-cyanoacrylate polymerises within seconds (inherent property of ethyl 2-cyanoacrylate based instant glues). Thus, very low determined monomer concentrations in water or moist media represent a non-steady state situation from which a defined effective concentration cannot be derived.

Applicant's summary and conclusion

Conclusions:
Tests in aqueous or moist media with ethyl 2-cyanoacrylate with the intent to determine effective concentrations or no effect concentrations cannot be performed due to technical reasons based on the chemical properties of the monomer.
Executive summary:

Tests in aqueous or moist media with ethyl 2-cyanoacrylate with the intent to determine effective concentrations or no effect concentrations cannot be performed due to technical reasons based on the chemical properties of the monomer. In presence of moisture ethyl 2-cyanoacrylate polymerises within seconds (inherent property of ethyl 2-cyanoacrylate based instant glues). Thus, very low determined monomer concentrations in water or moist media represent a non-steady state situation from which a defined effective concentration cannot be derived.