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Administrative data

Description of key information

- Skin: slightly irritating | rabbit | OECD 404 |ethyl-2-cyanoacrylate
- Eye: irritating | rabbit | no guideline followed |ethyl-2-cyanoacrylate
- Eye: not irritating | rabbit | OECD 405 | isobutyl 2-cyanoacrylate

Key value for chemical safety assessment

Additional information

There is a skin irritation study and a study of eye irritation from the ethyl-2-cyanoacrylate. In addition, there is an eye irritation study of isobutyl-2-cyanoacrylate.

The aim of the studies was to investigate possible reversible or irreversible irritancy and/or corrosion by the test substance following a single application to the intact skin or into the eyes of rabbits.

The methods and investigations of the skin irritation study were performed in conformance with the OECD Guideline 404. Thereby 0.5 g ethyl-2-cyanoacrylate was applied to intact skin areas and to abraded skin areas (covered with an gauze bandage) of each of 6 rabbits. The primary dermal irritation index (PDII) was found to be 0.87. That means that a slightly skin irritation was observed.

The methods and investigations of the eye irritation study with ethyl-2 cyanoacrylate were performed in conformance with the OECD Guideline 405. Hereby 0.1 ml ethyl-2-cyanoacrylate was applied into the conjunctival sac of the right eyes of each of the 9 rabbits. The duration of the exposure was 72 hours. The group mean score at 24 hours was 29.33. The group mean score at 48 and 72 hours were 15.33 and 9.66 respectively. That means that an irritation was observed.

In the eye irritation study with isobutyl-2-cyanoacrylate, Albino rabbits were anesthetized and the test substance was deposited with a needle in the middle of the corneal stroma. The test substance was also introduced under the conjunctiva and into the anterior chamber through the limbus. The animals were examined both clinically and histologically. The treated rabbit eyes were investigated 2 months after instillation of isobutyl-2-cyanoacrylate. In all the time no irritation was observed.

In conclusion, these results mean that ethyl-2-cyanoacrylate is slightly irritating to the skin of rabbits and irritating to the eyes of rabbits. In comparison, 2-isobutyl acrylate is not irritating to eyes of rabbits.

Justification for classification or non-classification