Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study and GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Water solubility
Water solubility:
24 µg/L
Temp.:
20 °C
pH:
6.6

Any other information on results incl. tables

The average water solubility of the test item Ethyl 2 -cyanoacrylate determined on two flow rates (25 mL/h and 12.5 mL/h) is 0.024 mg/L (24 µg/L, 24 ppb).

Annotation:

Due to its high reactivity, ethyl 2 -cyanoacrylate immediately polymerizes when getting in contact with water. Thus, the reported value of water solubility represents the very small concentration of residual monomers which are detectable in the aqueous phase. It has to considered that the test item ethyl 2 -cyanoacrylate is stabilized with hydrochinone according to the test certicicate supplied by the sponsor.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
The average water solubility of the test item Ethyl 2 -cyanoacrylate determined on two flow rates (25 mL/h and 12.5 mL/h) is 0.024 mg/L (24 µg/L, 24 ppb).
Annotation:
Due to its high reactivity, ethyl 2 -cyanoacrylate immediately polymerizes when getting in contact with water. Thus, the reported value of water solubility represents the very small concentration of residual monomers which are detectable in the aqueous phase. It has to considered that the test item ethyl 2 -cyanoacrylate is stabilized with hydrochinone according to the test certicicate supplied by the sponsor.