Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
the Partition coefficient can not be measured by any of the available standard methods incl. calculation methods. The determined value is the result of a non steady state situation and represents more the different reactivity of the substance in the both protic solvents water and octanol.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
GLP compliance:
yes (incl. certificate)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
0.776
Temp.:
22 °C
pH:
6.3

Applicant's summary and conclusion

Conclusions:
The test item Ethyl 2 -cyanoacrylate has a partition coefficient of : Log Pow = 0.776 (RSD 14%)
It has to be noted that the test item Ethyl 2 -cyanoacrylate shows high reactivity towards water and octanol. Due to spontaneous polymerization, only trace amount of residual monomers can be evaluated. The reactivity of the residual Ethyl 2 -cyanoacrylate leads to varying results, as can be interpreted from the reported relative standard deviations (RSD).
The determined value is the result of a non steady state situation and represents more the different reactivity of the substance in the both protic solvents water and octanol.