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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No GLP study. Documentation insufficient for an assessment of reliability.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Biphenyl
EC Number:
202-163-5
EC Name:
Biphenyl
Cas Number:
92-52-4
Molecular formula:
C12H10
IUPAC Name:
1,1'-biphenyl
Details on test material:
- Name of test material (as cited in study report): biphenyl

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg applied as finely ground sample
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
at 1, 24, 48, 72, 120 and 168 hrs
Number of animals or in vitro replicates:
6
Details on study design:
No data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
maximum mean total score (MMTS)
Basis:
mean
Time point:
other: 1 hour
Score:
11.6
Max. score:
110
Reversibility:
fully reversible within: 72 hours
Irritation parameter:
maximum mean total score (MMTS)
Basis:
mean
Time point:
other: 24 hours
Score:
8
Max. score:
110
Reversibility:
fully reversible within: 72 hours
Irritation parameter:
maximum mean total score (MMTS)
Basis:
mean
Time point:
other: 48 hours
Score:
0.6
Max. score:
110
Reversibility:
fully reversible within: 72 hours
Irritant / corrosive response data:
Immediate: discomfort was slight
10 Min.: Slight erythema, copious discharge
1 hour: Moderate erythema, very slight edema in five instances, copious discharge
24 hours: Slight erythema, copious discharge with slight whitish exudate
48 hours: Gradual improvement
72 hours: All scored zero

Any other information on results incl. tables

Immediate: discomfort was slight

10 Min.: Slight erythema, copious discharge

1 hour: Moderate erythema, very slight edema in five instances, copious discharge

24 hours: Slight erythema, copious discharge with slight whitish exudate

48 hours: Gradual improvement

72 hours: All scored zero

Applicant's summary and conclusion

Conclusions:
Slight erythema was observed with copious discharge at 1 and 24 hours (after 24 hours exposure to biphenyl). At 48 hours, gradual improvement was observed and the observed effects were fully reversible within 72 hours.