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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study was conducted prior to existence of guidelines and GLP and the report does not contain sufficient information to permit a meaningful evaluation of study results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1949
Report date:
1949

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No data
GLP compliance:
no
Remarks:
Study conducted prior to GLP
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Biphenyl
EC Number:
202-163-5
EC Name:
Biphenyl
Cas Number:
92-52-4
Molecular formula:
C12H10
IUPAC Name:
1,1'-biphenyl
Details on test material:
- Name of test material (as cited in study report): Diphenyl
- Physical state: not specified in the report
- Analytical purity: not specified in the report
- Impurities (identity and concentrations): not specified in the report
- Composition of test material, percentage of components: not specified in the report
- Isomers composition: not specified in the report
- Purity test date: not specified in the report
- Lot/batch No.: not specified in the report
- Expiration date of the lot/batch: not specified in the report
- Stability under test conditions: not specified in the report
- Storage condition of test material: not specified in the report

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: no data
Details on inhalation exposure:
Saturated vapor at room temperature (prepared by aerating a column packed with diphenyl and glass beads) and a mist produced by aerating the compund while heated to 170 °C in a bath of silicone.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
ca. 8 h
Concentrations:
no data
No. of animals per sex per dose:
6 rats
Control animals:
not specified

Results and discussion

Any other information on results incl. tables

8 hours exposure to diphenyl vapor at room temperature was not lethal to rats. These animals gained weight well in the 14 day observation period.

Similarly a group of 6 rats survived at 8 hour exposure to a mist produced by aerating the diphenyl while it was heated at 170°C.

Applicant's summary and conclusion

Conclusions:
Under the conditions of the study, 8 hours of exposure to diphenyl (substantially saturated vapor at room temperature and mists generated at 170 °C) were not considered to be lethal.