Registration Dossier
Registration Dossier
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EC number: 202-163-5 | CAS number: 92-52-4
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The GLP-study was not conducted according to any guidelines but the report contains sufficient data to permit a meaningful evaluation of study results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
- Type of study / information:
- In laboratory animals, increased liver mixed-function oxidase (MFO) activities and alterations in liver morphology are considered as two of the more sensitive indicators of polychlorinated biphenyls (PCB) exposure. Since the potential of chlorinated biphenyls to cause these effects has been considered to be dependent on the degree as well as position of chlorination, the purpose of this study was to compare the effects of biphenyl, monochlorobiphenyls (MCB's) and PCB mixtures on liver MFO activity and histopathology in male rats.
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- yes
Test material
- Reference substance name:
- Biphenyl
- EC Number:
- 202-163-5
- EC Name:
- Biphenyl
- Cas Number:
- 92-52-4
- Molecular formula:
- C12H10
- IUPAC Name:
- 1,1'-biphenyl
- Details on test material:
- - Name of test material (as cited in study report): Biphenyl
- Physical state: not specified in the report
- Analytical purity: Biphenyl - 100%,
- Impurities (identity and concentrations): not specified in the report
- Composition of test material, percentage of components: not specified in the report
- Isomers composition: not specified in the report
- Purity test date: not specified in the report
- Lot/batch No.: Biphenyl-OCR564:86
- Stability under test conditions: not specified in the report
- Storage condition of test material: not specified in the report
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Based on the conditions of the study, it was concluded that there are marked differences between the biological activities of chlorinated biphenyls in male rats and that monochlorobiphenyls (MCB's) and biphenyl were found to be less potent than typical polychlorinated biphenyls mixtures as inducing agents of hepatic MFO enzymes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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