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Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 January 1987 to 30 January 1987
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate
EC Number:
619-447-3
Cas Number:
99607-70-2
Molecular formula:
C18H22ClNO3
IUPAC Name:
heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate
Details on test material:
- Name of test material (as cited in study report): CGA185072 technical
- Physical state: solid
- Analytical purity: 91.6%

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 12-14 weeks
- Weight at study initiation: 2190 to 2320 g
- Housing: not specified
- Diet (e.g. ad libitum): not specified
- Water (e.g. ad libitum): not specified
- Acclimation period: not specified

IN-LIFE DATES: From: 27.01.1987 To: 30.01.1987

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
other: site moistened with distilled water containing 0.5% CMC and 0.1% polysorbate 80
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Concentration (if solution): not applicable

Duration of treatment / exposure:
4 hours
Observation period:
72 hours after removal of the treatment
Number of animals:
Three male rabbits
Details on study design:
TEST SITE
- Area of exposure: 36 cm2 of flank exposed, 0.5 g of test powder applied under small gauze
- Type of wrap if used: gauze patch covered by aluminium foil, secured around trunk by adhesive tape

REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified
- Time after start of exposure: not specified

SCORING SYSTEM: OECD Draize assessment method

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 48 hours
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 48 hours
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
Very slight erythema was evident for two rabbits at one and 24 hours. No other reactions were noted.
Other effects:
None

Applicant's summary and conclusion

Interpretation of results:
not irritating
Conclusions:
The substance was not irritating to the skin of rabbits.
Executive summary:

The skin irritation properties of the substance were tested under GLP to OECD TG 404 in an in vivo study with rabbits. The solid test material was applied to a gauze patch moisturized with distilled water containing 0.5% carboxymethyl cellulose and 0.1% polysorbate 80 which was placed on the shaved flank of three male albino New Zealand White rabbits. Flanks were shaved 24 hours before dosing. 0.5 g of cloquintocet-mexyl applied to the skin on a gauze patch, was covered with aluminium foil and fastened around the trunk by an adhesive tape to form an occlusive dressing. The patch was held in place for 4 hours. Skin reactions were evaluated according to the OECD scoring system after 1, 24, 48 and 72 hours. Very slight erythema was reported at the one hour observation time in all three rabbits and at 24 hours in two rabbits. The erythema had fully reversed at 48 hours. No oedema or other dermal effects were observed. Cloquintocet-mexyl is non-irritating to the skin.