heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate

Dissociation constant

Link to relevant study record(s)

Reference

Endpoint:

dissociation constant

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1996-10-23 - 1996-10-23 (experimental phase)

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 112 (Dissociation Constants in Water)

Deviations:

no

GLP compliance:

yes

Dissociating properties:

yes

No.:

#1

pKa:

3.55

Temp.:

20 °C

Remarks on result:

other: (basic dissociation constant)

Extrapolated from measurements in water with 20, 30 and 40 % ethanol, since the test substance is only sparingly soluble in water.

In aqueous solution the neutral from of the substance is predominantly present at pH >3.55, the protonic form at pH <3.55.

Conclusions:

The study is considered to be adequate and reliable.

Executive summary:

pK_a at 20 °C: 3.55 (basic dissociation constant)

In aqueous solution the neutral from of the substance is predominantly present at pH >3.55, the protonic form at pH 3.55.

Description of key information

pKa (Jäkel, 20 °C, basic): 3.55

Key value for chemical safety assessment

pKa at 20°C:

3.55

Additional information

A guideline study is available which is considered to be reliable and adequate, and is carried forward for use in risk assessment, classification and labelling.