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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1991-07-11 - 1991-12-17
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: internal Standard Operating Procedure
Deviations:
no
Principles of method if other than guideline:
Mixtures of the test substance with the test solvents were prepared (ensuring saturation). After centrifugation the clear solution was analysed by gas chromatography to determine the solubility of the test substance.
GLP compliance:
yes
Medium:
acetone
Solubility:
340 g/L
Temp.:
25 °C
Medium:
ethanol
Solubility:
190 g/L
Temp.:
25 °C
Medium:
other: n-hexane
Solubility:
11 g/L
Temp.:
25 °C
Medium:
n-octanol
Solubility:
140 g/L
Temp.:
25 °C
Medium:
toluene
Solubility:
360 g/L
Temp.:
25 °C
Test substance stable:
yes
Details on results:
The solubilities reported above have been corrected to two significant figures, and are given pro litre of saturated solution.
Conclusions:
The study is considered to be adequate and reliable.
Executive summary:

The solubility in organic solvents at 25 °C was determined as 340 g/L in acetone, 190 g/L in ethanol, 11 g/L in n-hexane, 140 g/L in n-octanol and in 360 g/L in toluene.

Description of key information

Solubility in organic solvents (Rodler, 25 °C, technical grade substance):

acetone: 340 g/L

ethanol: 190 g/L

n-hexane: 11 g/L

n-octanol: 140 g/L

toluene: 360 g/L

Key value for chemical safety assessment

Additional information

The available study is considered to be reliable and adequate.