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EC number: 619-447-3 | CAS number: 99607-70-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 March 1989 to 12 November 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Test conducted using individual samples contained in sealed brown glass tubes (10 mL). Sampling intervals determined in a pre-test and dependent on pH.
- Buffers:
- pH 5 buffer - 0.01M acetic acid + 0.01M sodium acetate
pH 7 buffer - 0.01M disodium hydrogen phosphate + 0.007M potassium dihydrogen phosphate
pH 9 buffer - 0.011M disodium tetraborate + 0.004M potassium dihydrogen phosphate
Experiment also conducted at pH 1 and pH13 using 0.1M HCl and 0.1M sodium hydroxide, respectively. - Estimation method (if used):
- Data analysed assuming first-order kinetics. Half-life calculated using t1/2 = ln2/k.
- Duration:
- 24 h
- pH:
- 1
- Temp.:
- 70.5 °C
- Initial conc. measured:
- ca. 0.4 other: ppm
- Duration:
- 208 h
- pH:
- 1
- Temp.:
- 51 °C
- Initial conc. measured:
- ca. 0.4 other: ppm
- Duration:
- 26 d
- pH:
- 1
- Temp.:
- 1.5 °C
- Initial conc. measured:
- ca. 0.4 other: ppm
- Duration:
- 9 d
- pH:
- 5
- Temp.:
- 70.5 °C
- Initial conc. measured:
- ca. 0.4 other: ppm
- Duration:
- 427 h
- pH:
- 5
- Temp.:
- 51 °C
- Initial conc. measured:
- ca. 0.4 other: ppm
- Duration:
- 30 d
- pH:
- 5
- Temp.:
- 25.2 °C
- Initial conc. measured:
- ca. 0.4 other: ppm
- Duration:
- 70 h
- pH:
- 7
- Temp.:
- 70.5 °C
- Initial conc. measured:
- ca. 0.4 other: ppm
- Duration:
- 96 h
- pH:
- 7
- Temp.:
- 51 °C
- Initial conc. measured:
- ca. 0.4 other: ppm
- Duration:
- 26 d
- pH:
- 7
- Temp.:
- 19.5
- Initial conc. measured:
- ca. 0.4 other: ppm
- Duration:
- 150 min
- pH:
- 9
- Temp.:
- 70 °C
- Initial conc. measured:
- ca. 0.4 other: ppm
- Duration:
- 1 035 min
- pH:
- 9
- Temp.:
- 51 °C
- Initial conc. measured:
- ca. 0.4 other: ppm
- Duration:
- 196 h
- pH:
- 9
- Temp.:
- 25.2 °C
- Initial conc. measured:
- ca. 0.4 other: ppm
- Transformation products:
- yes
- No.:
- #1
- Details on hydrolysis and appearance of transformation product(s):
- identity of transformation product: [(5-chloroquinolin-8-yl)oxy]acetic acid; CAS#: 88349-88-6; company code CGA153433
- % Recovery:
- > 93.9 - < 117
- pH:
- 1
- Temp.:
- 50 °C
- Duration:
- > 0.1 - < 96 h
- % Recovery:
- > 94.3 - < 100.6
- pH:
- 7
- Temp.:
- 70 °C
- Duration:
- > 0.1 - < 24 h
- pH:
- 1
- Temp.:
- 20 °C
- DT50:
- 29.8 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: r = > 0.98
- pH:
- 5
- Temp.:
- 20 °C
- DT50:
- 4.4 yr
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: r = > 0.99
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 133.7 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: r = 1.00
- pH:
- 9
- Temp.:
- 20 °C
- DT50:
- 6.6 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: r = > 0.98
- pH:
- 13
- Temp.:
- 25 °C
- DT50:
- < 5 min
- Remarks on result:
- other: r = 0.997
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance hydrolyses relatively slowly at pH 7 and 20 °C, with an estimated half-life of about 133.7 days. Hydrolysis is faster under basic conditions and slower under acidic conditions.
- Executive summary:
The hydrolysis of the substance was studied under GLP to OECD TG 111. Radiolabelled test material was used in the study at an inital concentration of about 0.4 ppm. Studies were conducted at various pH values of 1, 5, 7, 9 and 13, and test vessels were kept at intended environmental temperatures of 25, 50 and 70 °C. In strongly alkaline solution de-esterification was very rapid, slower at slightly alkaline pH and very slow in the range of pH 5 to 7. The following half-lives at 20 °C were derived from the experimental data: pH 1 = 29.8 days, pH 5 = 4.4 years, pH 7 = 133.7 days, pH 9 = 6.6 days and pH 13 = < 5 minutes (25°C). The free acid ([(5-chloroquinolin-8-yl)oxy]acetic acid; CAS#: 88349-88-6) was the sole hydrolysis product found in these experiments, therefore the transformation product can be considered as hydrolytically stable.
Reference
Description of key information
Hydrolysis of cloquintocet-mexyl was determined according to OECD test guidelines. The substance behaves as expected for an ester. In strongly alkaline solution de-esterification is very rapid, slower at slightly alkaline pH and very slow in the range of pH 5 to 7. The free acid (i.e. Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-; CAS#: 88349-88-6) was the sole hydrolysis product found in the experiment and is therefore considered to be hydrolytically stable.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 133.7 d
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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