Phosphorus trichloride

Developmental toxicity / teratogenicity

Administrative data

Endpoint:

developmental toxicity

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Detailed publication

Data source

Reference

Reference Type:

publication

Title:

Approach to long-term effects of phosphorus trichloride

Author:

He Y, Yang X, Zhong X, Deng L & Zhang J

Year:

1989

Bibliographic source:

Weisheng Dulixue Zazhi 3, 37-40

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Developmental toxicity study

GLP compliance:

no

Remarks:

: published study

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Phosphorus trichloride

EC Number:

231-749-3

EC Name:

Phosphorus trichloride

Cas Number:

7719-12-2

Molecular formula:

Cl3P

IUPAC Name:

phosphorus trichloride

Details on test material:

Phosphorus trichloride

Test animals

Species:

rat

Strain:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

Days 6-15

Frequency of treatment:

Daily

Duration of test:

Animals were sacrificed on Day 20

Doses / concentrations

Remarks:

Doses / Concentrations:
0, 0, 6.44, 9.7, 19.3 mg/kg bw
Basis:
actual ingested

Control animals:

other: positive + vehicle control groups

Details on study design:

Sex: female

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:

NOAEL

Effect level:

19.3 mg/kg bw/day

Basis for effect level:

other: developmental toxicity

Results (fetuses)

Details on embryotoxic / teratogenic effects:

Embryotoxic / teratogenic effects:no effects

Fetal abnormalities

Abnormalities:

not specified

Overall developmental toxicity

Developmental effects observed:

not specified

Any other information on results incl. tables

Body weight gain of dams: 
No effects in treated animals; reduction in positive controls

Effects on fertility:    neg   low   med   hig   pos 
Number of pregnant rats: 16    15    15    14    15
number of fetuses:       136   126   132   124   141
Corpora lutea:           218   205   217   206   150
corpora lutea per rat:   13.6  13.7  14.5  14.7  10
number of pups/litter:   8.13  7.73  8.47  8.06  8.2

dead fetuses:            3     1     3     10    0
% dead fetuses:          2.3   0.79  2.27  8.06  0

resorptions:             3     9     2     1     67
% resorptions:           2.2   7.1   1.52  0.81  47.5*

litters with resorptions:3     3     1     1     11
% Litter w. resorptions:12.3  20     6.67 7.14  73.3*

* = significant

                         neg    low    med     hig     pos
pups examined:           130    116    127     113     74   
size (cm):               3,84   3.89   3.84    3.79    3,64
tail (cm):               1,29   1,29   1,25    1,25    1,13 
weight of placenta (g):  0,43   0,49   0,46    0,47    0,51
frontal fontanella (mm): 3,14   2,95   3,06    2,97    2,93

There were no significant differences between treated and negative control animals. No malformations were detected. Skeletal development in treated foetuses was retarded but without a dose effect relation. Positive controls showed clear effects on fertility indices but no malformations.

Applicant's summary and conclusion

Conclusions:

No evidence of developmentla toxicity or teratogenicity was seen under the conditions of this study.

Executive summary:

No evidene of teratogenicity or developmental toxicity was seen in rats administered phosphorus trichloride on Days 6 -16 of gestation.