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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Review of study carried out on phosphorus containing compounds. Lacking information on the animals involved. No measured dose given.

Data source

Reference
Reference Type:
publication
Title:
Comparative Toxicity of Chloride Compounds of Phosphorus
Author:
Molodkina NN
Year:
1973
Bibliographic source:
Toksikologiya Novykh Prom, Khim, Veshch. 13: 107-114

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No guideline followed. The study involved the rabbit receiving 4 drops of the substance on the skin.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phosphorus trichloride
EC Number:
231-749-3
EC Name:
Phosphorus trichloride
Cas Number:
7719-12-2
Molecular formula:
Cl3P
IUPAC Name:
lambda6-phosphorus(3+) trichloride
Details on test material:
No further details provided.

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No further details given

Test system

Type of coverage:
not specified
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
4 drops of the test substance added to the skin of the rabbits.
Duration of treatment / exposure:
Not stated
Observation period:
Not stated
Number of animals:
Not given
Details on study design:
A single dose of 4 drops of the test substance was administered on a shorn section of hide 4x5 cm in size.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks:
No parameter measured
Basis:
mean
Time point:
other: All
Remarks on result:
other: Corrosive effects noted
Irritant / corrosive response data:
No response data was measured. It was noted that application of phosphorus trichloride resulted in the thickening of folds of the hide and the formation of deep hemorrhagic fissures.
Other effects:
No other effects noted.

Any other information on results incl. tables

Application of phosphorus trichloride resulted in skin thickening and the formation of deep haemorrhagic fissures.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Corrosive effects were obsereved under the conditions of this study.
Executive summary:

The application of four drops of phosphorus trichloride resulted in skin thickening and the formation of deep haemorrhagic fissures.