Registration Dossier
Registration Dossier
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EC number: 231-749-3 | CAS number: 7719-12-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Review of study carried out on phosphorus containing compounds. Lacking information on the animals involved. No measured dose given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative Toxicity of Chloride Compounds of Phosphorus
- Author:
- Molodkina NN
- Year:
- 1 973
- Bibliographic source:
- Toksikologiya Novykh Prom, Khim, Veshch. 13: 107-114
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline followed. The study involved the rabbit receiving 4 drops of the substance on the skin.
- GLP compliance:
- no
Test material
- Reference substance name:
- Phosphorus trichloride
- EC Number:
- 231-749-3
- EC Name:
- Phosphorus trichloride
- Cas Number:
- 7719-12-2
- Molecular formula:
- Cl3P
- IUPAC Name:
- phosphorus trichloride
- Details on test material:
- No further details provided.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No further details given
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 4 drops of the test substance added to the skin of the rabbits.
- Duration of treatment / exposure:
- Not stated
- Observation period:
- Not stated
- Number of animals:
- Not given
- Details on study design:
- A single dose of 4 drops of the test substance was administered on a shorn section of hide 4x5 cm in size.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks:
- No parameter measured
- Basis:
- mean
- Time point:
- other: All
- Remarks on result:
- other: Corrosive effects noted
- Irritant / corrosive response data:
- No response data was measured. It was noted that application of phosphorus trichloride resulted in the thickening of folds of the hide and the formation of deep hemorrhagic fissures.
- Other effects:
- No other effects noted.
Any other information on results incl. tables
Application of phosphorus trichloride resulted in skin thickening and the formation of deep haemorrhagic fissures.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Corrosive effects were obsereved under the conditions of this study.
- Executive summary:
The application of four drops of phosphorus trichloride resulted in skin thickening and the formation of deep haemorrhagic fissures.
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