Registration Dossier

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Detailed publication

Data source

Reference
Reference Type:
publication
Title:
Toxicity of phosphorus trichloride.
Author:
He Y, Zhou J, Zhong X, Yang X, Ou P, Zhang Y & Liang Y
Year:
1989
Bibliographic source:
Weishieng Dulixue Zazhi 3, 215-218

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Bone marrow micronucleus assay
GLP compliance:
no
Remarks:
: published study
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Phosphorus trichloride
EC Number:
231-749-3
EC Name:
Phosphorus trichloride
Cas Number:
7719-12-2
Molecular formula:
Cl3P
IUPAC Name:
lambda6-phosphorus(3+) trichloride
Details on test material:
Phosphorus trichloride

Test animals

Species:
mouse
Strain:
other: Kunming
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
5 days
Frequency of treatment:
Daily
Post exposure period:
24 hours
Doses / concentrations
Remarks:
Doses / Concentrations:
10.9, 21.88-43.75 mg/kg bw
Basis:
actual ingested
Control animals:
yes, concurrent vehicle

Examinations

Tissues and cell types examined:
Femoral bone marrow erythrocytes; spermatids

Results and discussion

Test results
Sex:
male
Genotoxicity:
negative

Any other information on results incl. tables

Administration of PCl3 did not induce chromosomal aberrations or micronuclei formation in bone marrow cells or abnormalities in the sperm of mice

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
Administration of PCl3 did not induce chromosomal aberrations or micronuclei formation in bone marrow cells or abnormalities in the sperm of mice
Executive summary:

No evidence of the induction chromosomal aberrations was seen in the femoral bone marrow or spermatids in this study in male mice.