Registration Dossier
Registration Dossier
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EC number: 231-749-3 | CAS number: 7719-12-2
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Detailed publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of phosphorus trichloride.
- Author:
- He Y, Zhou J, Zhong X, Yang X, Ou P, Zhang Y & Liang Y
- Year:
- 1 989
- Bibliographic source:
- Weishieng Dulixue Zazhi 3, 215-218
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Bone marrow micronucleus assay
- GLP compliance:
- no
- Remarks:
- : published study
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- Phosphorus trichloride
- EC Number:
- 231-749-3
- EC Name:
- Phosphorus trichloride
- Cas Number:
- 7719-12-2
- Molecular formula:
- Cl3P
- IUPAC Name:
- phosphorus trichloride
- Details on test material:
- Phosphorus trichloride
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kunming
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 5 days
- Frequency of treatment:
- Daily
- Post exposure period:
- 24 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10.9, 21.88-43.75 mg/kg bw
Basis:
actual ingested
- Control animals:
- yes, concurrent vehicle
Examinations
- Tissues and cell types examined:
- Femoral bone marrow erythrocytes; spermatids
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
Any other information on results incl. tables
Administration of PCl3 did not induce chromosomal aberrations or micronuclei formation in bone marrow cells or abnormalities in the sperm of mice
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Administration of PCl3 did not induce chromosomal aberrations or micronuclei formation in bone marrow cells or abnormalities in the sperm of mice - Executive summary:
No evidence of the induction chromosomal aberrations was seen in the femoral bone marrow or spermatids in this study in male mice.
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