Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: limited documentation; case report

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Phosphorus trichloride exposure - A follow up study of 27 exposed patients
Author:
Wason S, Gomolin I, Gross P & Lovejoy FH
Year:
1982
Bibliographic source:
Vet. Hum. Toxicol. 24, 17-18
Reference Type:
publication
Title:
Phosphorus trichloride toxicity
Author:
Wason S, Gomolin I, Gross P, Mariam S & Lovejoy FH
Year:
1984
Bibliographic source:
Am. J. Med. 77, 1039-1042

Materials and methods

Type of study / information:
Health effects following accidental exposure
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Investigation of health effects following accidental exposure
GLP compliance:
no
Remarks:
: not applicable

Test material

Constituent 1
Chemical structure
Reference substance name:
Phosphorus trichloride
EC Number:
231-749-3
EC Name:
Phosphorus trichloride
Cas Number:
7719-12-2
Molecular formula:
Cl3P
IUPAC Name:
lambda6-phosphorus(3+) trichloride
Details on test material:
phosphorus trichloride

Method

Details on study design:
Investigation of health effects following accidental exposure
Exposure assessment:
not specified

Results and discussion

Results:
Patients accidentally were exposed to PCl3 and its degradation products after a railroad accident. Symptoms of exposure included burning eyes (85%; mild conjunctivitis in 36%), shortness of breath (59%), throat irritation (59%) and lacrimation (59%), headache and nausea (48%), burning skin (44%), sputum production (41%), generalized or pleuritic chest pain (33%) and rash/itch (33%), wheezing (26%), blurred vision (22%), vomiting (15%) and abdominal pain (15%). Lactic dehydrogenase was increased in 22% of patients and recovered within four weeks after exposure. Pulmonary function tests showed a decrease of vital capacity in patients within 1/8 mile of the event. Hypoxaemia was recorded in these patients after two months.

Applicant's summary and conclusion

Executive summary:

Patients accidentally were exposed to PCl3 and its degradation products after a railroad accident. Symptoms of exposure included burning eyes (85%; mild conjunctivitis in 36%), shortness of breath (59%), throat irritation (59%) and lacrimation (59%), headache and nausea (48%), burning skin (44%), sputum production (41%), generalized or pleuritic chest pain (33%) and rash/itch (33%), wheezing (26%), blurred vision (22%), vomiting (15%) and abdominal pain (15%). Lactic dehydrogenase was increased in 22% of patients and recovered within four weeks after exposure. Pulmonary function tests showed a decrease of vital capacity in patients within 1/8 mile of the event. Hypoxaemia was recorded in these patients after two months.