Registration Dossier
Registration Dossier
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EC number: 231-749-3 | CAS number: 7719-12-2
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Detailed publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Approach to long-term effects of phosphorus trichloride
- Author:
- He Y, Yang X, Zhong X, Deng L & Zhang J
- Year:
- 1 989
- Bibliographic source:
- Weisheng Dulixue Zazhi 3, 37-40
Materials and methods
- Principles of method if other than guideline:
- Type: C37-001: structural aberrations in sperm cells
- GLP compliance:
- no
- Remarks:
- : published study
- Type of method:
- in vivo
Test material
- Reference substance name:
- Phosphorus trichloride
- EC Number:
- 231-749-3
- EC Name:
- Phosphorus trichloride
- Cas Number:
- 7719-12-2
- Molecular formula:
- Cl3P
- IUPAC Name:
- phosphorus trichloride
- Details on test material:
- phosphorus trichloride
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 4 h
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2, 33.5, 97.76 mg/m³
Basis:
no data
- No. of animals per sex per dose:
- 12 (male)
- Control animals:
- yes
- Details on study design:
- Duration of test: 45 or 60 days
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 97.76 mg/m³ air
- Sex:
- male
- Basis for effect level:
- other: No effects on sperm morphology
Observed effects
Any other information on results incl. tables
Sperm morphology was unaffected in animals exposed to PCl3
Applicant's summary and conclusion
- Conclusions:
- Sperm morphology was unaffected by inhalation exposure to PCl
- Executive summary:
Sperm morphology in male rats was unaffected by inhalation exposure to PCl3.
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