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Toxicological information

Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Detailed publication

Data source

Reference
Reference Type:
publication
Title:
Approach to long-term effects of phosphorus trichloride
Author:
He Y, Yang X, Zhong X, Deng L & Zhang J
Year:
1989
Bibliographic source:
Weisheng Dulixue Zazhi 3, 37-40

Materials and methods

Principles of method if other than guideline:
Type: C37-001: structural aberrations in sperm cells
GLP compliance:
no
Remarks:
: published study
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
Phosphorus trichloride
EC Number:
231-749-3
EC Name:
Phosphorus trichloride
Cas Number:
7719-12-2
Molecular formula:
Cl3P
IUPAC Name:
lambda6-phosphorus(3+) trichloride
Details on test material:
phosphorus trichloride

Test animals

Species:
rat
Sex:
male

Administration / exposure

Route of administration:
inhalation
Duration of treatment / exposure:
4 h
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
2, 33.5, 97.76 mg/m³
Basis:
no data
No. of animals per sex per dose:
12 (male)
Control animals:
yes
Details on study design:
Duration of test: 45 or 60 days

Results and discussion

Effect levels

Dose descriptor:
NOAEC
Effect level:
97.76 mg/m³ air
Sex:
male
Basis for effect level:
other: No effects on sperm morphology

Observed effects

No effects were observed on sperm morphology

Any other information on results incl. tables

Sperm morphology was unaffected in animals exposed to PCl3

Applicant's summary and conclusion

Conclusions:
Sperm morphology was unaffected by inhalation exposure to PCl
Executive summary:

Sperm morphology in male rats was unaffected by inhalation exposure to PCl3.